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    CstF50 Cleavage stimulation factor 50 kD subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43734, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CstF50provided by FlyBase
    Official Full Name
    Cleavage stimulation factor 50 kD subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039867
    Locus tag
    Dmel_CG2261
    See related
    AllianceGenome:FB:FBgn0039867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2261; CstF-50; Dmel\CG2261
    Summary
    Predicted to be involved in mRNA 3'-end processing. Located in nucleoplasm. Part of mRNA cleavage stimulating factor complex. Is expressed in organism. Orthologous to human CSTF1 (cleavage stimulation factor subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CstF50 in Genome Data Viewer
    Location:
    100D1-100D1; 3-102 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31735503..31736963, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27561225..27562685, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR34046 Neighboring gene tramtrack Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation elongation factor 1 alpha 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hexameric architecture of CstF supported by CstF-50 homodimerization domain structure. Moreno-Morcillo M, et al. RNA, 2011 Mar. PMID 21233223, Free PMC Article
    2. A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage. Gallicchio L, et al. Genes Dev, 2024 Aug 20. PMID 39111825,
    3. A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs. Sullivan KD, et al. Mol Cell, 2009 May 15. PMID 19450530, Free PMC Article
    4. Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript. Zhang Z, et al. Mol Cell, 2006 Jan 6. PMID 16387654
    5. P-TEFb is critical for the maturation of RNA polymerase II into productive elongation in vivo. Ni Z, et al. Mol Cell Biol, 2008 Feb. PMID 18070927, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage stimulating factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage stimulating factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mRNA cleavage stimulating factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cleavage stimulation factor 50 kD subunit
    Names
    CG2261-PA
    CstF-50
    CstF50-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31735503..31736963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143626.3 → NP_651883.1  cleavage stimulation factor 50 kD subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651883.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9V0
      Related
      FBpp0085224
      Conserved Domains (3) summary
      cd00200
      Location:98 → 417
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:113 → 164
      7WD40; WD40 repeat [structural motif]
      pfam16699
      Location:10 → 63
      CSTF1_dimer; Cleavage stimulation factor subunit 1, dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9V0 Q9V9V0

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