U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hsc70-5 Heat shock protein 70 cognate 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36583, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Hsc70-5provided by FlyBase
    Official Full Name
    Heat shock protein 70 cognate 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0001220
    Locus tag
    Dmel_CG8542
    See related
    AllianceGenome:FB:FBgn0001220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8542; dhsc70; dHSC70-5; Dmel\CG8542; Hsc-5; HSC-70; hsc-70-5; Hsc-70-5; hsc5; Hsc5; HSC5; hsc70; Hsc70; HSC70; hsc70-5; HSC70-5; Hsp-c5; HSP70m1; l(2)k04907; mtHsc70
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; mitochondrial protein-transporting ATPase activity; and protein folding chaperone. Involved in mitochondrion organization and positive regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and larval muscle cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (Hsp70) member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Hsc70-5 in Genome Data Viewer
    Location:
    50E6-50E6; 2-69 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14252598..14256192, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10140103..10143697, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing, arthropod-specific, member 1 Neighboring gene Multi drug resistance 50 Neighboring gene uncharacterized protein Neighboring gene beta1,4-N-acetylgalactosaminyltransferase A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The BCL-2 family protein BCL-RAMBO interacts and cooperates with GRP75 to promote its apoptosis signaling pathway. Xu J, et al. Sci Rep, 2023 Aug 28. PMID 37640805, Free PMC Article
    2. Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy. Jo DS, et al. Autophagy, 2020 Nov. PMID 31964216, Free PMC Article
    3. Analysis of Mdr50: a Drosophila P-glycoprotein/multidrug resistance gene homolog. Gerrard B, et al. Genomics, 1993 Jul. PMID 7691715
    4. Ginseng protein protects against mitochondrial dysfunction and neurodegeneration by inducing mitochondrial unfolded protein response in Drosophila melanogaster PINK1 model of Parkinson's disease. Liu M, et al. J Ethnopharmacol, 2020 Jan 30. PMID 31562951
    5. Effects of alcohol on gene expression in neural cells. Wilke N, et al. EXS, 1994. PMID 8032172

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila.
      Title: Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitochondrial protein-transporting ATPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of PAM complex, Tim23 associated import motor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    heat shock protein 70 cognate 5
    Names
    70 kDa heat shock protein, mitochondrial 1
    CG8542-PA
    CG8542-PB
    Hsc70-5-PA
    Hsc70-5-PB
    Hsp cognate 5
    heat shock 70 kDa protein cognate 5
    heat shock protein cognate 5
    heat shock protein cognate 71
    mortalin
    NP_001286414.1
    NP_523741.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14252598..14256192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079017.2 → NP_523741.2  heat shock protein 70 cognate 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523741.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29845, Q9V6Z7
      UniProtKB/TrEMBL
      A0A0B4LFD2
      Related
      FBpp0086694, FBtr0087568
      Conserved Domains (3) summary
      cd11733
      Location:51 → 428
      HSPA9-like_NBD; Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins
      PRK00290
      Location:51 → 666
      dnaK; molecular chaperone DnaK; Provisional
      pfam15290
      Location:566 → 642
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    2. NM_001299485.1 → NP_001286414.1  heat shock protein 70 cognate 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29845, Q9V6Z7
      UniProtKB/TrEMBL
      A0A0B4LFD2
      Conserved Domains (3) summary
      cd11733
      Location:51 → 428
      HSPA9-like_NBD; Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins
      PRK00290
      Location:51 → 666
      dnaK; molecular chaperone DnaK; Provisional
      pfam15290
      Location:566 → 642
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFD2 A0A0B4LFD2
    P29845.2 P29845

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous