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    RpL15 Ribosomal protein L15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3354918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RpL15provided by FlyBase
    Official Full Name
    Ribosomal protein L15provided by FlyBase
    Primary source
    FLYBASE:FBgn0028697
    Locus tag
    Dmel_CG17420
    See related
    AllianceGenome:FB:FBgn0028697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    80Fi; CG17420; CG40199; Dmel\CG17420; DmRpL15; l(3)80Fi; l(3)Lh2; L15; L15e; l2; lethal 2; rpl15; rpL15; Rpl15; RPL15
    Summary
    A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 12. Orthologous to human RPL15 (ribosomal protein L15). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RpL15 in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (27267255..27268445)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3LHet NW_001848857.1 (2397791..2398981)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA Me18S-G1358c Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene verthandi Neighboring gene long non-coding RNA:CR46250 Neighboring gene Dead box protein 80 Neighboring gene long non-coding RNA:CR46482 Neighboring gene pseudo Neighboring gene eukaryotic translation initiation factor 4B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome. Schwaiger M, et al. Genome Res, 2010 Jun. PMID 20435908, Free PMC Article
    2. Characterization of Gfat1 (zeppelin) and Gfat2, Essential Paralogous Genes Which Encode the Enzymes That Catalyze the Rate-Limiting Step in the Hexosamine Biosynthetic Pathway in Drosophila melanogaster. Cotsworth S, et al. Cells, 2022 Jan 27. PMID 35159258, Free PMC Article
    3. Effects of Mutations in the Drosophila melanogaster Rif1 Gene on the Replication and Underreplication of Pericentromeric Heterochromatin in Salivary Gland Polytene Chromosomes. Kolesnikova TD, et al. Cells, 2020 Jun 19. PMID 32575592, Free PMC Article
    4. Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila. Yu Z, et al. Genetics, 2013 Sep. PMID 23833182, Free PMC Article
    5. A genetic and molecular characterization of two proximal heterochromatic genes on chromosome 3 of Drosophila melanogaster. Schulze SR, et al. Genetics, 2005 Apr. PMID 15687284, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein L15
    Names
    CG17420-PA
    CG17420-PB
    CG17420-PC
    CG17420-PE
    CG17420-PF
    CG17420-PG
    CG17420-PH
    CG17420-PI
    RpL15-PA
    RpL15-PB
    RpL15-PC
    RpL15-PE
    RpL15-PF
    RpL15-PG
    RpL15-PH
    RpL15-PI
    lethal (3) 80Fi
    lethal 2
    lethal2
    ribosomal L15

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      27267255..27268445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258469.1 → NP_001245398.1  ribosomal protein L15, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245398.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8Y561, O17445, Q7PL86, Q9W5N1
      UniProtKB/TrEMBL
      A8Y560
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15

    2. NM_001258468.1 → NP_001245397.1  ribosomal protein L15, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245397.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8Y561, O17445, Q7PL86, Q9W5N1
      UniProtKB/TrEMBL
      A8Y560
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15

    3. NM_001258466.1 → NP_001245395.1  ribosomal protein L15, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245395.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8Y561, O17445, Q7PL86, Q9W5N1
      UniProtKB/TrEMBL
      A8Y560
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15

    4. NM_001258467.1 → NP_001245396.1  ribosomal protein L15, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245396.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8Y561, O17445, Q7PL86, Q9W5N1
      UniProtKB/TrEMBL
      A8Y560
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15

    5. NM_001015156.2 → NP_001015156.1  ribosomal protein L15, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015156.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8Y561, O17445, Q7PL86, Q9W5N1
      UniProtKB/TrEMBL
      A8Y560
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15

    6. NM_001110959.3 → NP_001104429.2  ribosomal protein L15, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104429.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8Y561, O17445, Q7PL86, Q9W5N1
      UniProtKB/TrEMBL
      A8Y560
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15

    7. NM_001110960.2 → NP_001104430.1  ribosomal protein L15, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104430.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8Y561, O17445, Q7PL86, Q9W5N1
      UniProtKB/TrEMBL
      A8Y560
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15

    8. NM_001015155.3 → NP_001015155.1  ribosomal protein L15, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015155.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8Y561, O17445, Q7PL86, Q9W5N1
      UniProtKB/TrEMBL
      A8Y560
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 191
      Ribosomal_L15e; Ribosomal L15
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8Y560 A8Y560
    O17445.1 O17445

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