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    RpS12 Ribosomal protein S12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39480, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RpS12provided by FlyBase
    Official Full Name
    Ribosomal protein S12provided by FlyBase
    Primary source
    FLYBASE:FBgn0286213
    Locus tag
    Dmel_CG11271
    See related
    AllianceGenome:FB:FBgn0286213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH29995; CG11271; Dmel\CG11271; dRpS12; l(3)s2783; rpS12; RpS12E; RS12; S12; S12e; su(comp)3L-1
    Old locus tag
    CG11271
    Summary
    A structural constituent of ribosome. Predicted to be involved in maintenance of translational fidelity and ribosomal small subunit biogenesis. Located in cytosolic ribosome. Part of small ribosomal subunit. Is expressed in several structures, including embryonic/larval midgut primordium; epithelial tube; ganglia; gut section; and mesoderm. Orthologous to human RPS12 (ribosomal protein S12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See RpS12 in Genome Data Viewer
    Location:
    69F5-69F5; 3-39 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13023352..13024762)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13016452..13017862)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45445 Neighboring gene Isoprenylcysteine carboxyl methyltransferase Neighboring gene Adenosine kinase 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Zinc finger MYND-type containing 10 Neighboring gene long non-coding RNA:CR45172 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reducing the aneuploid cell burden - cell competition and the ribosome connection. Baker NE, et al. Dis Model Mech, 2022 Nov 1. PMID 36444717, Free PMC Article
    2. HumanaFly: high-throughput transgenesis and expression of breast cancer transcripts in Drosophila eye discovers the RPS12-Wingless signaling axis. Katanaev VL, et al. Sci Rep, 2020 Dec 3. PMID 33273532, Free PMC Article
    3. A potential link between p53, cell competition and ribosomopathy in mammals and in Drosophila. Baker NE, et al. Dev Biol, 2019 Feb 1. PMID 30513308, Free PMC Article
    4. Ribosomal Protein S12e Has a Distinct Function in Cell Competition. Kale A, et al. Dev Cell, 2018 Jan 8. PMID 29316439, Free PMC Article
    5. Telomere loss provokes multiple pathways to apoptosis and produces genomic instability in Drosophila melanogaster. Titen SW, et al. Genetics, 2008 Dec. PMID 18845846, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in maintenance of translational fidelity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S12
    Names
    40S ribosomal component
    40S ribosomal protein S12
    CG11271-PB
    RpS12-PB
    S12
    minute
    ribosomal protein
    ribosomal protein S12e
    ribosomal protein gene 12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13023352..13024762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168534.4 → NP_729866.1  ribosomal protein S12 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729866.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P80455, Q0E8F1, Q9VU40
      Related
      FBpp0075612
      Conserved Domains (1) summary
      pfam01248
      Location:23 → 118
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P80455.2 P80455

    Gene LinkOut

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