twf twinfilin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: twfprovided by FlyBase
Official Full Name: twinfilinprovided by FlyBase
Primary source: FLYBASE:FBgn0038206
Locus tag: Dmel_CG3172
See related: AllianceGenome:FB:FBgn0038206
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A6; CG3172; Dmel\CG3172; Twf
Summary: Enables actin binding activity. Involved in several processes, including actin filament depolymerization; border follicle cell migration; and mushroom body development. Located in cytoplasm and plasma membrane. Is expressed in several structures, including border follicle cell; brain; mechanosensory chaeta; and ovary. Orthologous to human TWF1 (twinfilin actin binding protein 1) and TWF2 (twinfilin actin binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88A9-88A9; 3-54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14122654..14124474)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9948376..9950196)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Twinfilin promotes actin turnover in multiple cellular processes that are highly dependent on actin dynamics.
Title: Drosophila twinfilin is required for cell migration and synaptic endocytosis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin monomer binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sequestering of actin monomers	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: twinfilin

Names: CG3172-PA; twf-PA; twinfillin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

14122654..14124474

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142081.4 → NP_650338.1 twinfilin [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650338.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VFM9

Related

FBpp0082352

Conserved Domains (2) summary

cd11284
Location:176 → 310

ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins

cd11285
Location:4 → 142

ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins