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    Vha68-3 Vacuolar H[+] ATPase 68kD subunit 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vha68-3provided by FlyBase
    Official Full Name
    Vacuolar H[+] ATPase 68kD subunit 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0032464
    Locus tag
    Dmel_CG5075
    See related
    AllianceGenome:FB:FBgn0032464
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5075; Dmel\CG5075; vha67-3; Vha68; vha68-3
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of proton-transporting V-type ATPase complex. Is expressed in several structures, including adult head; anterior endoderm; ejaculatory bulb; ejaculatory duct; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vha68-3 in Genome Data Viewer
    Location:
    34A3-34A3; 2-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12978786..12981293)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12978786..12981293)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 68 kDa subunit 2 Neighboring gene Yip1 domain-containing 1 Neighboring gene Vacuolar H[+] ATPase 68kD subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. Greco TM, et al. Cell Syst, 2022 Apr 20. PMID 35148841, Free PMC Article
    2. Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex. Portela M, et al. Sci Signal, 2018 Jun 5. PMID 29871910, Free PMC Article
    3. The V-ATPase V1 subunit A1 is required for rhodopsin anterograde trafficking in Drosophila. Zhao H, et al. Mol Biol Cell, 2018 Jul 1. PMID 29742016, Free PMC Article
    4. Histone deacetylase-mediated regulation of endolysosomal pH. Prasad H, et al. J Biol Chem, 2018 May 4. PMID 29567836, Free PMC Article
    5. Genome-wide mapping of matrix attachment regions in Drosophila melanogaster. Pathak RU, et al. BMC Genomics, 2014 Nov 25. PMID 25424749, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism IC
    Inferred by Curator
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IC
    Inferred by Curator
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of proton-transporting V-type ATPase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar H[+] ATPase 68kD subunit 3
    Names
    CG5075-PA
    V-ATPase V1 subunit A1
    Vha68-3-PA
    vacuolar H[+] ATPase subunit 68-3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12978786..12981293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135751.3 → NP_609595.1  vacuolar H[+] ATPase 68kD subunit 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609595.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK47
      Related
      FBpp0080002
      Conserved Domains (4) summary
      cd01134
      Location:207 → 579
      V_A-ATPase_A; V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...
      TIGR01042
      Location:141 → 729
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
      pfam00306
      Location:597 → 738
      ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
      pfam02874
      Location:143 → 205
      ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T464 Q8T464
    Q9VK47 Q9VK47

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