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    Kua Kua [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35300, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kuaprovided by FlyBase
    Official Full Name
    Kuaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032850
    Locus tag
    Dmel_CG10723
    See related
    AllianceGenome:FB:FBgn0032850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38B.18; CG10723; Dmel\CG10723
    Summary
    Predicted to enable plasmanylethanolamine desaturase activity. Predicted to be located in membrane. Is expressed in embryonic antennal sense organ. Orthologous to human PEDS1-UBE2V1 (PEDS1-UBE2V1 readthrough) and PEDS1 (plasmanylethanolamine desaturase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Kua in Genome Data Viewer
    Location:
    38B6-38C1; 2-54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20097581..20103375)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20097581..20103375)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene nessun dorma Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new function evolved from gene fusion. Long M. Genome Res, 2000 Nov. PMID 11076848
    2. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. Thomson TM, et al. Genome Res, 2000 Nov. PMID 11076860, Free PMC Article
    3. Molecular Profiling of the Drosophila Antenna Reveals Conserved Genes Underlying Olfaction in Insects. Mohapatra P, et al. G3 (Bethesda), 2019 Nov 5. PMID 31527046, Free PMC Article
    4. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Mukherjee C, et al. Cell Metab, 2020 Aug 4. PMID 32531201, Free PMC Article
    5. Map position and expression of the genes in the 38 region of Drosophila. Butler H, et al. Genetics, 2001 Aug. PMID 11514449, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 20099516-20099570 mobile_element_type = transposon:INE-1{}4062

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plasmanylethanolamine desaturase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kua
    Names
    CG10723-PA
    CG10723-PB
    CG10723-PC
    CG10723-PD
    Kua-PA
    Kua-PB
    Kua-PC
    Kua-PD
    NP_001188856.1
    NP_001260620.1
    NP_001260621.1
    NP_610026.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20097581..20103375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273691.1 → NP_001260620.1  Kua, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260620.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3B5
      Conserved Domains (1) summary
      pfam10520
      Location:124 → 301
      TMEM189_B_dmain; B domain of TMEM189, localization domain

    2. NM_001273692.1 → NP_001260621.1  Kua, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260621.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3B5
      Conserved Domains (1) summary
      pfam10520
      Location:124 → 301
      TMEM189_B_dmain; B domain of TMEM189, localization domain

    3. NM_001201927.2 → NP_001188856.1  Kua, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188856.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3B5
      Conserved Domains (1) summary
      pfam10520
      Location:124 → 301
      TMEM189_B_dmain; B domain of TMEM189, localization domain

    4. NM_136182.2 → NP_610026.1  Kua, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3B5
      Related
      FBpp0080868
      Conserved Domains (1) summary
      pfam10520
      Location:124 → 301
      TMEM189_B_dmain; B domain of TMEM189, localization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3B5 Q9V3B5

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