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    heca headcase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43604, updated on 17-Dec-2024

    Summary

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    Official Symbol
    hecaprovided by FlyBase
    Official Full Name
    headcaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010113
    Locus tag
    Dmel_CG15532
    See related
    AllianceGenome:FB:FBgn0010113
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15532; Dmel\CG15532; hac; hdc; Hdc; HDC; l(3)B4-3-20; psg12
    Summary
    Involved in several processes, including autophagic cell death; regulation of cell development; and terminal branching, open tracheal system. Located in axon; dendrite; and perinuclear region of cytoplasm. Is expressed in several structures, including embryonic/larval tracheal section; ganglia; gonad; imaginal disc primordium; and larval imaginal tissue. Orthologous to human HECA (hdc homolog, cell cycle regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See heca in Genome Data Viewer
    Location:
    99E4-99F2; 3-100 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30277932..30372382)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26103654..26198104)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46113 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46114 Neighboring gene Ferritin 1 heavy chain homologue Neighboring gene long non-coding RNA:CR45570 Neighboring gene Ferritin 2 light chain homologue

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intestinal stem cell ablation reveals differential requirements for survival in response to chemical challenge. Resende LP, et al. Dev Biol, 2017 Apr 1. PMID 28104389, Free PMC Article
    2. Dual role for Headcase in hemocyte progenitor fate determination in Drosophila melanogaster. Kharrat B, et al. PLoS Genet, 2024 Oct. PMID 39466810, Free PMC Article
    3. headcase, an imaginal specific gene required for adult morphogenesis in Drosophila melanogaster. Weaver TA, et al. Development, 1995 Dec. PMID 8575315
    4. Location and functions of Inebriated in the Drosophila eye. Borycz J, et al. Biol Open, 2018 Jul 23. PMID 30037884, Free PMC Article
    5. Evidence for Dynamic Network Regulation of Drosophila Photoreceptor Function from Mutants Lacking the Neurotransmitter Histamine. Dau A, et al. Front Neural Circuits, 2016. PMID 27047343, Free PMC Article

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dual role for Headcase in hemocyte progenitor fate determination in Drosophila melanogaster.
      Title: Dual role for Headcase in hemocyte progenitor fate determination in Drosophila melanogaster.
    2. Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells.
      Title: Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells.
    3. Results show that hdc expression in the lymph gland is developmentally regulated, and plays an indispensable role in blocking premature lamellocyte differentiation. Hdc acts in the posterior signaling center, upstream of the Hedgehog and Decapentaplegic regulatory pathways, which normally maintain the prohemocyte state of medullary zone cells.
      Title: Headcase is a Repressor of Lamellocyte Fate in Drosophila melanogaster.
    4. The study demonstrated that HDC mutation provide mechanistic explanations of how synaptic feedback connections in photoreceptor output and novel insight into the operation and design of dynamic network regulation of sensory neurons.
      Title: Evidence for Dynamic Network Regulation of Drosophila Photoreceptor Function from Mutants Lacking the Neurotransmitter Histamine.
    5. Our epistasis experiments with known regulators of dendrite pruning reveal hdc as a founding member of a new pathway downstream of ecdysone signaling.
      Title: An interaction screen identifies headcase as a regulator of large-scale pruning.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 30317381-30324914 mobile_element_type = transposon:roo{}1458

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in autophagic cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in instar larval or pupal development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in terminal branching, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    headcase
    Names
    CG15532-PA
    CG15532-PB
    CG15532-PC
    CG15532-PD
    Fusion-6
    heca-PA
    heca-PB
    heca-PC
    heca-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30277932..30372382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276174.1 → NP_001263103.1  headcase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263103.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI61
      Conserved Domains (2) summary
      pfam15353
      Location:69 → 172
      HECA; Headcase protein family homologue
      pfam16002
      Location:444 → 634
      Headcase; Headcase protein

    2. NM_079853.4 → NP_524592.2  headcase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524592.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI61
      Related
      FBpp0084983
      Conserved Domains (2) summary
      pfam15353
      Location:69 → 172
      HECA; Headcase protein family homologue
      pfam16002
      Location:444 → 634
      Headcase; Headcase protein

    3. NM_176591.3 → NP_788768.1  headcase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788768.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24480, Q95SY2, Q9N2M8, Q9VA84
      Related
      FBpp0084985
      Conserved Domains (2) summary
      pfam15353
      Location:69 → 172
      HECA; Headcase protein family homologue
      pfam16002
      Location:444 → 634
      Headcase; Headcase protein

    4. NM_170478.3 → NP_733357.1  headcase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733357.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMI6
      Related
      FBpp0084984
      Conserved Domains (1) summary
      pfam16002
      Location:14 → 185
      Headcase; Headcase protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KI61 A0A0B4KI61
    Q8IMI6 Q8IMI6
    Q9N2M8.2 Q9N2M8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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