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    Atat alpha-tubulin acetylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39086, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atatprovided by FlyBase
    Official Full Name
    alpha-tubulin acetylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035989
    Locus tag
    Dmel_CG3967
    See related
    AllianceGenome:FB:FBgn0035989
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alphaTAT; ATAT; Atat1; CG3967; dalphaTAT; Dmel\CG3967; dTat; dTAT; Tat
    Summary
    Enables tubulin N-acetyltransferase activity. Involved in behavioral response to ethanol. Predicted to be located in microtubule. Is expressed in several structures, including adult head; embryonic head sensory system; ganglia; larval nervous system; and sensory nervous system primordium. Orthologous to human ATAT1 (alpha tubulin acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Atat in Genome Data Viewer
    Location:
    67B5-67B5; 3-29 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9413596..9426758, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9406696..9419858, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 67B Neighboring gene uncharacterized protein Neighboring gene Cleavage and polyadenylation specific factor 5 Neighboring gene uncharacterized protein Neighboring gene astray Neighboring gene SHC-adaptor protein Neighboring gene Ribosomal protein S17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-enzymatic Activity of the α-Tubulin Acetyltransferase αTAT Limits Synaptic Bouton Growth in Neurons. Coombes CE, et al. Curr Biol, 2020 Feb 24. PMID 31928876, Free PMC Article
    2. CryoET shows cofilactin filaments inside the microtubule lumen. Ventura Santos C, et al. EMBO Rep, 2023 Nov 6. PMID 37702953, Free PMC Article
    3. α-Tubulin acetylation at lysine 40 regulates dendritic arborization and larval locomotion by promoting microtubule stability in Drosophila. Niu X, et al. PLoS One, 2023. PMID 36827311, Free PMC Article
    4. ATAT1-enriched vesicles promote microtubule acetylation via axonal transport. Even A, et al. Sci Adv, 2019 Dec. PMID 31897425, Free PMC Article
    5. Drosophila CG17003/leaky (lky) is required for microtubule acetylation in early germ cells in Drosophila ovary. Antel M, et al. PLoS One, 2022. PMID 36342916, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tubulin N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin N-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in alpha-tubulin acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-tubulin acetylase
    Names
    Atat-PA
    Atat-PB
    Atat-PC
    Atat-PD
    Atat-PE
    Atat-PF
    CG3967-PA
    CG3967-PB
    CG3967-PC
    CG3967-PD
    CG3967-PE
    CG3967-PF
    alpha-tubulin acetyltransferase
    NP_001261628.1
    NP_648309.1
    NP_648310.1
    NP_729487.1
    NP_729488.1
    NP_729489.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9413596..9426758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140053.2 → NP_648310.1  alpha-tubulin acetylase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648310.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95S14, Q9VSY4, Q9VSY5
      Related
      FBpp0076209, FBtr0076481
      Conserved Domains (1) summary
      pfam05301
      Location:79 → 189
      Mec-17; Touch receptor neuron protein Mec-17

    2. NM_170630.2 → NP_729487.1  alpha-tubulin acetylase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729487.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95S14, Q9VSY4, Q9VSY5
      Related
      FBpp0076210
      Conserved Domains (1) summary
      pfam05301
      Location:79 → 189
      Mec-17; Touch receptor neuron protein Mec-17

    3. NM_170631.1 → NP_729488.1  alpha-tubulin acetylase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729488.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95S14, Q9VSY4, Q9VSY5
      Related
      FBpp0076211, FBtr0076483
      Conserved Domains (1) summary
      pfam05301
      Location:79 → 189
      Mec-17; Touch receptor neuron protein Mec-17

    4. NM_140052.2 → NP_648309.1  alpha-tubulin acetylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648309.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95S14, Q9VSY4, Q9VSY5
      Related
      FBpp0076212
      Conserved Domains (1) summary
      pfam05301
      Location:79 → 189
      Mec-17; Touch receptor neuron protein Mec-17

    5. NM_170632.2 → NP_729489.1  alpha-tubulin acetylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729489.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEN1
      Related
      FBpp0076208
      Conserved Domains (1) summary
      pfam05301
      Location:79 → 189
      Mec-17; Touch receptor neuron protein Mec-17

    6. NM_001274699.1 → NP_001261628.1  alpha-tubulin acetylase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261628.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEN1
      Conserved Domains (1) summary
      pfam05301
      Location:79 → 189
      Mec-17; Touch receptor neuron protein Mec-17
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEN1 M9PEN1
    Q9VSY4.2 Q9VSY4

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