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    Coa7 Cytochrome c oxidase assembly factor 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355158, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Coa7provided by FlyBase
    Official Full Name
    Cytochrome c oxidase assembly factor 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0039965
    Locus tag
    Dmel_CG13865
    See related
    AllianceGenome:FB:FBgn0039965
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13865; CG40301; COA7; dCOA7; Dmel\CG13865; FBgn0039965
    Summary
    Predicted to be active in mitochondrial intermembrane space. Is expressed in adult head; adult heart; and organism. Used to study spinocerebellar ataxia with axonal neuropathy type 3. Human ortholog(s) of this gene implicated in spinocerebellar ataxia with axonal neuropathy type 3. Orthologous to human COA7 (cytochrome c oxidase assembly factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Coa7 in Genome Data Viewer
    Location:
    20F3-20F4; 1-66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (23013495..23016586)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (22415331..22418422)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45010 Neighboring gene alpha1,3-fucosyltransferase C Neighboring gene Rab21 Neighboring gene zydeco Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in COA7 cause spinocerebellar ataxia with axonal neuropathy. Higuchi Y, et al. Brain, 2018 Jun 1. PMID 29718187, Free PMC Article
    2. Identification of CR43467 encoding a long non-coding RNA as a novel genetic interactant with dFIG4, a CMT-causing gene. Shimada S, et al. Exp Cell Res, 2020 Jan 1. PMID 31704059
    3. A nerve-wracking buzz: lessons from Drosophila models of peripheral neuropathy and axon degeneration. Bhattacharya MRC. Front Aging Neurosci, 2023. PMID 37614471, Free PMC Article
    4. Competition within Introns: Splicing Wins over Polyadenylation via a General Mechanism. Tikhonov M, et al. Acta Naturae, 2013 Oct. PMID 24455183, Free PMC Article
    5. Recent Advances in Drosophila Models of Charcot-Marie-Tooth Disease. Kitani-Morii F, et al. Int J Mol Sci, 2020 Oct 8. PMID 33049996, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in respiratory chain complex IV assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase assembly factor 7
    Names
    CG13865-PA
    CG13865-PB
    CG13865-PC
    Coa7-PA
    Coa7-PB
    Coa7-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      23013495..23016586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298612.1 → NP_001285541.1  cytochrome c oxidase assembly factor 7, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285541.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHN1, Q9W5N0
      UniProtKB/TrEMBL
      X2JEN8
      Conserved Domains (3) summary
      smart00671
      Location:214 → 247
      SEL1; Sel1-like repeats
      COG0790
      Location:28 → 248
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:88 → 117
      SLR; SLR repeat [structural motif]

    2. NM_001042858.2 → NP_001036323.1  cytochrome c oxidase assembly factor 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036323.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHN1, Q9W5N0
      UniProtKB/TrEMBL
      X2JEN8
      Conserved Domains (3) summary
      smart00671
      Location:214 → 247
      SEL1; Sel1-like repeats
      COG0790
      Location:28 → 248
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:88 → 117
      SLR; SLR repeat [structural motif]

    3. NM_001042859.2 → NP_001036324.1  cytochrome c oxidase assembly factor 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036324.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W5N0
      Conserved Domains (2) summary
      COG0790
      Location:22 → 130
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:48 → 78
      SLR; SLR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W5N0.1 Q9W5N0
    X2JEN8 X2JEN8

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