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    NK7.1 NK7.1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NK7.1provided by FlyBase
    Official Full Name
    NK7.1provided by FlyBase
    Primary source
    FLYBASE:FBgn0024321
    Locus tag
    Dmel_CG8524
    See related
    AllianceGenome:FB:FBgn0024321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8524; Dmel\CG8524; NK-7.1; NK7
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including cephalic vascular remnant; embryonic/larval midgut primordium; gland; gut section; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NK7.1 in Genome Data Viewer
    Location:
    88B4-88B6; 3-55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14329413..14372951, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10155135..10198673, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene SET domain containing 8 Neighboring gene Aftiphilin Neighboring gene ATP synthase, subunit E Neighboring gene spindle B Neighboring gene Dynein axonemal assembly factor 5 Neighboring gene long non-coding RNA:CR44943 Neighboring gene scotti

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of a novel homeobox (NK-7.1) containing gene, DmHboxNK-7.1, from Drosophila melanogaster. Sakoyama Y, et al. Biochem Genet, 2002 Apr. PMID 12017506
    2. Simultaneous cellular and molecular phenotyping of embryonic mutants using single-cell regulatory trajectories. Secchia S, et al. Dev Cell, 2022 Feb 28. PMID 35176234, Free PMC Article
    3. HEATR2 plays a conserved role in assembly of the ciliary motile apparatus. Diggle CP, et al. PLoS Genet, 2014 Sep. PMID 25232951, Free PMC Article
    4. Remodelling of a homeobox gene cluster by multiple independent gene reunions in Drosophila. Chan C, et al. Nat Commun, 2015 Mar 5. PMID 25739651
    5. The specification and function of enteroendocrine cells in Drosophila and mammals: a comparative review. Guo X, et al. FEBS J, 2022 Aug. PMID 34115929

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NK7.1
    Names
    CG8524-PA
    CG8524-PB
    CG8524-PC
    CG8524-PD
    Dm.HboxNK-7.1
    NK7.1-PA
    NK7.1-PB
    NK7.1-PC
    NK7.1-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14329413..14372951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260174.3 → NP_001247103.1  NK7.1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247103.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F9W347, Q9VFK4
      Conserved Domains (1) summary
      pfam00046
      Location:397 → 449
      Homeobox; Homeobox domain

    2. NM_142100.3 → NP_650357.2  NK7.1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650357.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F9W347, Q9VFK4
      Related
      FBpp0082400
      Conserved Domains (1) summary
      pfam00046
      Location:397 → 449
      Homeobox; Homeobox domain

    3. NM_001316524.1 → NP_001303453.1  NK7.1, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F9W347, Q9VFK4
      Conserved Domains (1) summary
      pfam00046
      Location:397 → 449
      Homeobox; Homeobox domain

    4. NM_169580.3 → NP_731904.1  NK7.1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F9W347, Q9VFK4
      Related
      FBpp0082401
      Conserved Domains (1) summary
      pfam00046
      Location:397 → 449
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61640 O61640
    Q9VFK4 Q9VFK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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