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    Alas Aminolevulinate synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37815, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alasprovided by FlyBase
    Official Full Name
    Aminolevulinate synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020764
    Locus tag
    Dmel_CG3017
    See related
    AllianceGenome:FB:FBgn0020764
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alas; ALAS; CG3017; dALAS; Dmel\CG3017
    Summary
    Predicted to enable 5-aminolevulinate synthase activity. Involved in chitin-based cuticle development. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in Bolwig organ primordium; adult head; embryonic/larval oenocyte; organism; and ring gland. Human ortholog(s) of this gene implicated in cutaneous porphyria; erythropoietic protoporphyria; hemochromatosis; sideroblastic anemia; and sideroblastic anemia 1. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1) and ALAS2 (5'-aminolevulinate synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Alas in Genome Data Viewer
    Location:
    60A14-60A14; 2-105 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23964772..23966757)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19852295..19854280)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene alpha-catenin related Neighboring gene uncharacterized protein Neighboring gene Flavin-containing monooxygenase 1 Neighboring gene uncharacterized protein Neighboring gene orange Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Relevant expression of Drosophila heme oxygenase is necessary for the normal development of insect tissues. Cui L, et al. Biochem Biophys Res Commun, 2008 Dec 26. PMID 18983822
    2. Structure and regulated expression of the delta-aminolevulinate synthase gene from Drosophila melanogaster. Ruiz de Mena I, et al. J Biol Chem, 1999 Dec 24. PMID 10601299
    3. Catalytic activity and expression of two flavin-containing monooxygenases from Drosophila melanogaster. Scharf ME, et al. Arch Insect Biochem Physiol, 2004 Sep. PMID 15352153
    4. Diphenyl diselenide [(PhSe)2] inhibits Drosophila melanogaster delta-aminolevulinate dehydratase (delta-ALA-D) gene transcription and enzyme activity. Golombieski RM, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2008 Mar. PMID 17936691
    5. The ABC transporter Snu and the extracellular protein Snsl cooperate in the formation of the lipid-based inward and outward barrier in the skin of Drosophila. Zuber R, et al. Eur J Cell Biol, 2018 Mar. PMID 29306642

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results demonstrated that alas and CG33156 are indispensable for ecdysteroidogenesis.
      Title: Deep sequencing of the prothoracic gland transcriptome reveals new players in insect ecdysteroidogenesis.
    2. aminolevulinate synthase activity, which initiates heme biosynthesis in the mitochondrion, is needed for the formation of a dityrosine-based barrier that confers resistance to the internal hydrostatic pressure
      Title: δ-Aminolevulinate synthase is required for apical transcellular barrier formation in the skin of the Drosophila larva.
    3. Delta-ALA-D from D. melanogaster and M.musculus has a different profile of optimum pH and different sensitivity for diphenyl diselenide and lead, two inhibitors.
      Title: Diphenyl diselenide [(PhSe)2] inhibits Drosophila melanogaster delta-aminolevulinate dehydratase (delta-ALA-D) gene transcription and enzyme activity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5-aminolevulinate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5-aminolevulinate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5-aminolevulinate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in erythrocyte development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hemoglobin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrapyrrole biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aminolevulinate synthase
    Names
    Alas-PA
    Alas/50-Aminolevulinate synthase
    CG3017-PA
    delta-Aminolevulinate synthase
    delta-aminolevulinic acid synthase
    NP_477281.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23964772..23966757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057933.5 → NP_477281.1  aminolevulinate synthase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477281.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18680, Q8T4G6
      Related
      FBpp0072060
      Conserved Domains (2) summary
      COG0156
      Location:95 → 490
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
      cl18945
      Location:93 → 495
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18680 O18680
    Q8T4G6 Q8T4G6

    Gene LinkOut

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