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    CG14881 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41990, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14881provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038425
    Locus tag
    Dmel_CG14881
    See related
    AllianceGenome:FB:FBgn0038425
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14881
    Summary
    Predicted to enable (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity. Predicted to be involved in fatty acid biosynthetic process. Predicted to be active in mitochondrion. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human ARMC7 (armadillo repeat containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14881 in Genome Data Viewer
    Location:
    89B16-89B16; 3-58 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16434899..16436066)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12260621..12261788)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Threonine-AGT 1-4 Neighboring gene uncharacterized protein Neighboring gene Farnesyl transferase beta subunit Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene endosomal maturation defective Neighboring gene Tetratricopeptide repeat domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure and population genetics of the breakpoints associated with the cosmopolitan chromosomal inversion In(3R)Payne in Drosophila melanogaster. Matzkin LM, et al. Genetics, 2005 Jul. PMID 15781702, Free PMC Article
    2. Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease. Lavoy S, et al. Genetics, 2018 Aug. PMID 29907646, Free PMC Article
    3. Regional modulation of a stochastically expressed factor determines photoreceptor subtypes in the Drosophila retina. Thanawala SU, et al. Dev Cell, 2013 Apr 15. PMID 23597484, Free PMC Article
    4. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14881-PA
    CG14881-PB
    NP_650541.1
    NP_732137.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16434899..16436066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142284.4 → NP_650541.1  uncharacterized protein Dmel_CG14881, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650541.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY94
      Related
      FBpp0082739

    2. NM_169718.3 → NP_732137.1  uncharacterized protein Dmel_CG14881, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732137.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEV6
      Related
      FBpp0082738
      Conserved Domains (1) summary
      cd03449
      Location:171 → 283
      R_hydratase; (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SY94 Q8SY94
    Q9VEV6 Q9VEV6

    Gene LinkOut

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