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    sff sugar-free frosting [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39732, updated on 27-Dec-2024

    Summary

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    Official Symbol
    sffprovided by FlyBase
    Official Full Name
    sugar-free frostingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036544
    Locus tag
    Dmel_CG6114
    See related
    AllianceGenome:FB:FBgn0036544
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BRSK1; CG6114; Dmel\CG6114
    Summary
    Predicted to enable tau-protein kinase activity. Involved in neuromuscular junction development and protein N-linked glycosylation. Predicted to be located in cytoplasm and nucleus. Is expressed in adult head; larval peripheral nervous system; larval ventral nerve cord; and ventral midline of embryo. Orthologous to human BRSK1 (BR serine/threonine kinase 1) and BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sff in Genome Data Viewer
    Location:
    72A4-72B1; 3-43 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15900156..15924861, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15893256..15917961, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pH-sensitive chloride channel 1 Neighboring gene long non-coding RNA:CR44051 Neighboring gene long non-coding RNA:CR44050 Neighboring gene Protein kinase, cAMP-dependent, catalytic subunit 3 Neighboring gene GXIVsPLA2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of protein N-glycosylation in neural transmission. Scott H, et al. Glycobiology, 2014 May. PMID 24643084, Free PMC Article
    2. Sugar-free frosting, a homolog of SAD kinase, drives neural-specific glycan expression in the Drosophila embryo. Baas S, et al. Development, 2011 Feb. PMID 21205799, Free PMC Article
    3. Drosophila LKB1 is required for the assembly of the polarized actin structure that allows spermatid individualization. Couderc JL, et al. PLoS One, 2017. PMID 28767695, Free PMC Article
    4. The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination. Crump JG, et al. Neuron, 2001 Jan. PMID 11182085
    5. Synaptogenesis: insights from worm and fly. Jin Y. Curr Opin Neurobiol, 2002 Feb. PMID 11861167

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sugar-free frosting
    Names
    CG6114-PA
    CG6114-PB
    CG6114-PC
    SNF1-related
    sff-PA
    sff-PB
    sff-PC
    NP_001261901.1
    NP_001261902.1
    NP_648814.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15900156..15924861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274972.1 → NP_001261901.1  sugar-free frosting, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261901.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFS3, Q95T82
      Conserved Domains (3) summary
      smart00220
      Location:18 → 269
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14340
      Location:298 → 350
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:16 → 269
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2

    2. NM_001274973.1 → NP_001261902.1  sugar-free frosting, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261902.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFM1, Q95T82
      Conserved Domains (3) summary
      smart00220
      Location:18 → 269
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14340
      Location:298 → 350
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:16 → 269
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2

    3. NM_140557.5 → NP_648814.3  sugar-free frosting, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648814.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T82, Q9VUV4
      Related
      FBpp0088511
      Conserved Domains (3) summary
      smart00220
      Location:18 → 269
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14340
      Location:298 → 350
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:16 → 269
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFM1 M9PFM1
    M9PFS3 M9PFS3
    Q95T82 Q95T82
    Q9VUV4 Q9VUV4

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