TfIIB Transcription factor IIB [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: TfIIBprovided by FlyBase
Official Full Name: Transcription factor IIBprovided by FlyBase
Primary source: FLYBASE:FBgn0004915
Locus tag: Dmel_CG5193
See related: AllianceGenome:FB:FBgn0004915
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5193; Dmel\CG5193; dmTFIIB; dTfIIB; dTFIIB; tfIIb; Tfiib; TFIIB; TfllB
Summary: Enables TBP-class protein binding activity. Involved in mRNA transcription by RNA polymerase II and transcriptional start site selection at RNA polymerase II promoter. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; head mesoderm; larval visceral muscle cell; and trunk mesoderm. Orthologous to human GTF2B (general transcription factor IIB). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10431338..10433116)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10431338..10433116)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	IEA Inferred from Electronic Annotation more info
enables TBP-class protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in transcription preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in transcriptional start site selection at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcriptional start site selection at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info

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