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    Haspin haspin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355064, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Haspinprovided by FlyBase
    Official Full Name
    haspinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0046706
    Locus tag
    Dmel_CG40080
    See related
    AllianceGenome:FB:FBgn0046706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD07633; CG40080; Dmel\CG40080; haspin; HASPIN
    Summary
    Enables histone H3T3 kinase activity. Involved in positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric; positive regulation of protein localization to chromatin; and post-translational protein modification. Located in chromatin and nuclear lamina. Is expressed in amnioserosa and embryonic/larval plasmatocyte. Orthologous to human HASPIN (histone H3 associated protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Haspin in Genome Data Viewer
    Location:
    41A1-41A1; 2-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4014111..4049342)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (3199376..3234607)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene RYamide Neighboring gene antisense RNA:CR45139 Neighboring gene unextended Neighboring gene uncharacterized protein Neighboring gene Ribonuclease kappa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone H3 Threonine Phosphorylation Regulates Asymmetric Histone Inheritance in the Drosophila Male Germline. Xie J, et al. Cell, 2015 Nov 5. PMID 26522592, Free PMC Article
    2. Haspin-like proteins: a new family of evolutionarily conserved putative eukaryotic protein kinases. Higgins JM. Protein Sci, 2001 Aug. PMID 11468364, Free PMC Article
    3. Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation. Antel M, et al. Nat Commun, 2022 Jul 9. PMID 35810185, Free PMC Article
    4. Centromere assembly and non-random sister chromatid segregation in stem cells. Carty BL, et al. Essays Biochem, 2020 Sep 4. PMID 32406510
    5. Asymmetric assembly of centromeres epigenetically regulates stem cell fate. Dattoli AA, et al. J Cell Biol, 2020 Apr 6. PMID 32328637, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Haspin kinase modulates nuclear architecture and Polycomb-dependent gene silencing.
      Title: Haspin kinase modulates nuclear architecture and Polycomb-dependent gene silencing.
    2. These data provide insight into how Hasp and Hig construct the synaptic cleft matrix and regulate the differentiation of cholinergic synapses, and also illuminate a previously unidentified architecture within synaptic clefts
      Title: The Matrix Proteins Hasp and Hig Exhibit Segregated Distribution within Synaptic Clefts and Play Distinct Roles in Synaptogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H3T3 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3T3 kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H3T3 kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of maintenance of sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-translational protein modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear lamina IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    haspin
    Names
    CG40080-PA
    Haspin-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      4014111..4049342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001015349.4 → NP_001015349.2  haspin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015349.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83103, Q7PLN2
      Conserved Domains (2) summary
      pfam12330
      Location:479 → 545
      DUF3635; Domain of unknown function (DUF3635)
      cl21453
      Location:252 → 426
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83103.1 P83103

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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