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    or orange [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    orprovided by FlyBase
    Official Full Name
    orangeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003008
    Locus tag
    Dmel_CG3029
    See related
    AllianceGenome:FB:FBgn0003008
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AP-3sigma; aps3; cg3029; CG3029; Dmel\CG3029; Or; sigma3
    Summary
    Predicted to enable cargo receptor activity. Involved in compound eye pigmentation. Predicted to be part of AP-3 adaptor complex. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in organism. Orthologous to human AP3S1 (adaptor related protein complex 3 subunit sigma 1) and AP3S2 (adaptor related protein complex 3 subunit sigma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    60A14-60A14; 2-105 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23967939..23968943)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19855462..19856466)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Aminolevulinate synthase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene morula

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The seizure locus encodes the Drosophila homolog of the HERG potassium channel. Wang XJ, et al. J Neurosci, 1997 Feb 1. PMID 8994043, Free PMC Article
    2. Muller "Elements" in Drosophila: How the Search for the Genetic Basis for Speciation Led to the Birth of Comparative Genomics. Schaeffer SW. Genetics, 2018 Sep. PMID 30166445, Free PMC Article
    3. Distinct requirements for the AP-3 adaptor complex in pigment granule and synaptic vesicle biogenesis in Drosophila melanogaster. Mullins C, et al. Mol Gen Genet, 2000 Jul. PMID 10954086
    4. The molecular machinery for lysosome biogenesis. Mullins C, et al. Bioessays, 2001 Apr. PMID 11268039
    5. Eye color as an indicator of behavior: revisiting Worthy and Scott. Elias VL, et al. Psychol Rep, 2008 Jun. PMID 18763448

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cargo receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in compound eye pigmentation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in eye pigment biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in lysosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of AP-3 adaptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    orange
    Names
    CG3029-PA
    adaptor protein complex 3, sigma subunit
    or-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23967939..23968943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080532.4 → NP_536793.1  orange [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GQM6, Q9W1E8
      Related
      FBpp0072061
      Conserved Domains (1) summary
      cd14834
      Location:1 → 146
      AP3_sigma; AP-3 complex subunit sigma
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1E8 Q9W1E8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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