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    CG10470 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35174, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10470provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032746
    Locus tag
    Dmel_CG10470
    See related
    AllianceGenome:FB:FBgn0032746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-37B-2; B2; Dmel\CG10470; TU37B2; TuB2; TUB2
    Summary
    Predicted to enable calcium channel activity. Predicted to be involved in endoplasmic reticulum calcium ion homeostasis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 1. Orthologous to human TMCO1 (transmembrane and coiled-coil domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10470 in Genome Data Viewer
    Location:
    37B12-37B12; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19049076..19049884)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19049076..19049884)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Catecholamines up Neighboring gene Tetratricopeptide repeat domain 19 Neighboring gene Acinus Neighboring gene lethal (2) 37Bb Neighboring gene Regulatory particle non-ATPase 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A LIM-homeodomain combinatorial code for motor-neuron pathway selection. Thor S, et al. Nature, 1999 Jan 7. PMID 9892357
    2. The Drosophila islet gene governs axon pathfinding and neurotransmitter identity. Thor S, et al. Neuron, 1997 Mar. PMID 9115734
    3. Effects of Ddc cluster lethal alleles on ovary growth, attachment, and egg production in Drosophila. McCrady E, et al. J Exp Zool, 1994 May 1. PMID 8176361
    4. The Wilhelmine E. Key 1992 Invitational lecture. Phenotypic analysis of the Dopa decarboxylase gene cluster mutants in Drosophila melanogaster. Wright TR. J Hered, 1996 May-Jun. PMID 8683095
    5. The genetic and molecular organization of the Dopa decarboxylase gene cluster of Drosophila melanogaster. Stathakis DG, et al. Genetics, 1995 Oct. PMID 8647399, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10470-PA
    transcription unit 37B2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19049076..19049884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136092.2 → NP_609936.1  uncharacterized protein Dmel_CG10470 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609936.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IA62, Q9VJ11
      Related
      FBpp0080690
      Conserved Domains (1) summary
      pfam01956
      Location:5 → 162
      DUF106; Integral membrane protein DUF106
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IA62 Q8IA62
    Q9VJ11 Q9VJ11

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