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    LManI Lysosomal alpha-mannosidase I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34436, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LManIprovided by FlyBase
    Official Full Name
    Lysosomal alpha-mannosidase Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032253
    Locus tag
    Dmel_CG5322
    See related
    AllianceGenome:FB:FBgn0032253
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5322; Dmel\CG5322
    Summary
    Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LManI in Genome Data Viewer
    Location:
    31E4-31E5; 2-42 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10452677..10457241, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10452677..10457241, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lonely heart Neighboring gene pickpocket 10 Neighboring gene Lysosomal alpha-mannosidase II Neighboring gene RluA pseudouridine synthase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterisation of class I and II α-mannosidases from Drosophila melanogaster. Nemčovičová I, et al. Glycoconj J, 2013 Dec. PMID 23979800
    2. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Heinrichsen ET, et al. Mol Metab, 2014 Feb. PMID 24567903, Free PMC Article
    3. Role of Drosophila HP1 in euchromatic gene expression. Cryderman DE, et al. Dev Dyn, 2005 Mar. PMID 15704177
    4. Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. Rosenbaum EE, et al. PLoS Genet, 2014 May. PMID 24785692, Free PMC Article
    5. The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Sieber MH, et al. Cell Metab, 2009 Dec. PMID 19945405, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal alpha-mannosidase I
    Names
    CG5322-PA
    CG5322-PB
    LManI-PA
    LManI-PB
    NP_001260350.1
    NP_609407.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10452677..10457241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273421.1 → NP_001260350.1  lysosomal alpha-mannosidase I, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260350.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QV3, Q9VKV2
      Conserved Domains (3) summary
      cd10810
      Location:2 → 276
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      pfam07748
      Location:536 → 941
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      pfam09261
      Location:323 → 398
      Alpha-mann_mid; Alpha mannosidase, middle domain

    2. NM_135563.3 → NP_609407.1  lysosomal alpha-mannosidase I, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609407.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QV3, Q9VKV2
      Related
      FBpp0079632
      Conserved Domains (3) summary
      cd10810
      Location:2 → 276
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      pfam07748
      Location:536 → 941
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      pfam09261
      Location:323 → 398
      Alpha-mann_mid; Alpha mannosidase, middle domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKV2 Q9VKV2

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