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    Acat2 Acetyl-CoA acetyltransferase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38147, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acat2provided by FlyBase
    Official Full Name
    Acetyl-CoA acetyltransferase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035203
    Locus tag
    Dmel_CG9149
    See related
    AllianceGenome:FB:FBgn0035203
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACAA1; ACAT; ACAT2; CG9149; Dmel\CG9149
    Summary
    Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; and gut section. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Acat2 in Genome Data Viewer
    Location:
    61F5-61F5; 3-0 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1302944..1304717)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1302944..1304717)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene supercoiling factor Neighboring gene Rac1 Neighboring gene 5' nucleotidase A Neighboring gene Ctr9 Neighboring gene sturkopf

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional genomic analysis of the 61D-61F region of the third chromosome of Drosophila melanogaster. Wei HC, et al. Genome, 2003 Dec. PMID 14663523
    2. The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila. Ashton-Beaucage D, et al. Cell, 2010 Oct 15. PMID 20946983
    3. Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse. Song T, et al. Cell Res, 2023 Jun. PMID 37055592, Free PMC Article
    4. Inhibition of mevalonate pathway by macrophage-specific delivery of atorvastatin prevents their pro-inflammatory polarisation. Krejčová G, et al. Insect Mol Biol, 2024 Aug. PMID 38367277
    5. Drosophila mRNA Localization During Later Development: Past, Present, and Future. Hughes SC, et al. Front Genet, 2019. PMID 30899273, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetyl-CoA C-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Acetyl-CoA acetyltransferase 2
    Names
    Acat2-PA
    B-ketoacyl-CoA thiolase
    CG9149-PA
    NP_612094.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1302944..1304717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138250.3 → NP_612094.2  Acetyl-CoA acetyltransferase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612094.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0H6, T1W0I3
      Related
      FBpp0072560
      Conserved Domains (2) summary
      PRK05790
      Location:1 → 391
      PRK05790; putative acyltransferase; Provisional
      cd00751
      Location:5 → 390
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXL6 Q8SXL6
    Q9W0H6 Q9W0H6

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