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    PPP1R15 Protein phosphatase 1 regulatory subunit 15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37820, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PPP1R15provided by FlyBase
    Official Full Name
    Protein phosphatase 1 regulatory subunit 15provided by FlyBase
    Primary source
    FLYBASE:FBgn0034948
    Locus tag
    Dmel_CG3825
    See related
    AllianceGenome:FB:FBgn0034948
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3825; dGADD34; Dm-GADD34; Dmel\CG3825; dPPP1R15; gadd34; Gadd34; GADD34; ppp1r15
    Summary
    Enables protein phosphatase 1 binding activity. Predicted to be involved in response to endoplasmic reticulum stress. Located in endoplasmic reticulum. Is expressed in several structures, including embryonic brain; embryonic/larval hindgut; epithelium; larval central nervous system; and yolk sac. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A) and PPP1R15B (protein phosphatase 1 regulatory subunit 15B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PPP1R15 in Genome Data Viewer
    Location:
    60A15-60A16; 2-105 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23975599..23977255, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19863122..19864778, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene morula Neighboring gene Sox box protein 14 Neighboring gene Peptidylglycine-alpha-hydroxylating monooxygenase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The small compound Icerguastat reduces muscle defects in oculopharyngeal muscular dystrophy through the PERK pathway of the unfolded protein response. Naït-Saïdi R, et al. Open Biol, 2023 Apr. PMID 37042114, Free PMC Article
    2. Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation. Chambers JE, et al. Elife, 2015 Mar 16. PMID 25774599, Free PMC Article
    3. Maintenance of proteostasis by Drosophila Rer1 is essential for competitive cell survival and Myc-driven overgrowth. Paul PK, et al. PLoS Genet, 2024 Feb. PMID 38408084, Free PMC Article
    4. Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development. Malzer E, et al. J Cell Sci, 2013 Mar 15. PMID 23418347, Free PMC Article
    5. New Drosophila models to uncover the intrinsic and extrinsic factors that mediate the toxicity of the human prion protein. Myers RR, et al. Dis Model Mech, 2022 Apr 1. PMID 35142350, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase type 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 15
    Names
    CG3825-PA
    PPP1R15-PA
    growth arrest and DNA-damage-inducible 34

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23975599..23977255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138019.3 → NP_611863.1  protein phosphatase 1 regulatory subunit 15 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611863.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1E4
      Related
      FBpp0072113
      Conserved Domains (1) summary
      pfam10488
      Location:243 → 309
      PP1c_bdg; Phosphatase-1 catalytic subunit binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1E4 Q9W1E4

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