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    RtcB RtcB RNA ligase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35220, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RtcBprovided by FlyBase
    Official Full Name
    RtcB RNA ligaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032781
    Locus tag
    Dmel_CG9987
    See related
    AllianceGenome:FB:FBgn0032781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9987; Dmel\CG9987; Rtcb
    Summary
    Predicted to enable RNA ligase (GTP) activity. Involved in positive regulation of tRNA processing and tRNA processing. Predicted to be part of tRNA-splicing ligase complex. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RtcB in Genome Data Viewer
    Location:
    37E1-37E1; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19430643..19432444)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19430643..19432444)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Paxillin Neighboring gene lectin-37Db Neighboring gene uncharacterized protein Neighboring gene Alkaline phosphatase 12 Neighboring gene Rab9 Neighboring gene uncharacterized protein Neighboring gene Ran GTPase activating protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia. Schmidt CA, et al. Biol Open, 2022 Mar 15. PMID 35132432, Free PMC Article
    2. Models of axon regeneration in Drosophila. Brace EJ, et al. Exp Neurol, 2017 Jan. PMID 26996133, Free PMC Article
    3. Metazoan tRNA introns generate stable circular RNAs in vivo. Lu Z, et al. RNA, 2015 Sep. PMID 26194134, Free PMC Article
    4. Molecular determinants of metazoan tricRNA biogenesis. Schmidt CA, et al. Nucleic Acids Res, 2019 Jul 9. PMID 31032518, Free PMC Article
    5. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA ligase (GTP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA splicing, via endonucleolytic cleavage and ligation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA splicing, via endonucleolytic cleavage and ligation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA-splicing ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA-splicing ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RtcB RNA ligase
    Names
    CG9987-PA
    RtcB-PA
    RtcB-like
    NP_609965.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19430643..19432444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136121.2 → NP_609965.1  RtcB RNA ligase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609965.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VIW7
      Related
      FBpp0080746
      Conserved Domains (2) summary
      COG1690
      Location:67 → 506
      RtcB; RNA-splicing ligase RtcB, repairs tRNA damage [Translation, ribosomal structure and biogenesis]
      pfam01139
      Location:67 → 506
      RtcB; tRNA-splicing ligase RtcB
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIW7.1 Q9VIW7

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