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    HP1e Heterochromatin Protein 1e [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41108, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HP1eprovided by FlyBase
    Official Full Name
    Heterochromatin Protein 1eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037675
    Locus tag
    Dmel_CG8120
    See related
    AllianceGenome:FB:FBgn0037675
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8120; Dmel\CG8120; HP1; hp1e; HP1E
    Summary
    Predicted to enable chromatin binding activity and methylated histone binding activity. Involved in heterochromatin formation and sperm DNA condensation. Located in chromatin. Is expressed in testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HP1e in Genome Data Viewer
    Location:
    85D11-85D11; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9321770..9322361)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5147492..5148083)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 16A Neighboring gene long non-coding RNA:CR46350 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitotic fidelity requires transgenerational action of a testis-restricted HP1. Levine MT, et al. Elife, 2015 Jul 7. PMID 26151671, Free PMC Article
    2. Functions of HP1 proteins in transcriptional regulation. Schoelz JM, et al. Epigenetics Chromatin, 2022 May 7. PMID 35526078, Free PMC Article
    3. A rapidly evolving genomic toolkit for Drosophila heterochromatin. Levine MT, et al. Fly (Austin), 2013 Jul-Sep. PMID 23519206, Free PMC Article
    4. Expression of hp1 family genes and their plausible role in formation of flamenco phenotype in D. melanogaster. Lavrenov AR, et al. Biochemistry (Mosc), 2014 Nov. PMID 25540013
    5. Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup. Beck EA, et al. Sci Rep, 2015 Nov 25. PMID 26603658, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm DNA condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pericentric heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heterochromatin protein 1e
    Names
    CG8120-PA
    HP1e-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9321770..9322361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141621.2 → NP_649878.1  heterochromatin protein 1e [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649878.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPG0, Q9VHG0
      Related
      FBpp0081494
      Conserved Domains (2) summary
      cd00024
      Location:25 → 67
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      pfam01393
      Location:113 → 164
      Chromo_shadow; Chromo shadow domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHG0 Q9VHG0

    Gene LinkOut

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