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    Dora Dorado [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50356, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Doraprovided by FlyBase
    Official Full Name
    Doradoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085430
    Locus tag
    Dmel_CG34401
    See related
    AllianceGenome:FB:FBgn0085430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15037; CG17757; CG32542; CG34401; CG7307; CG7317; Dmel\CG34401; dora; pelado; pldo; Zswim8
    Old locus tag
    CG17757; CG32542; Dmel_CG17757; Dmel_CG32542
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of miRNA catabolic process and target-directed miRNA degradation. Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in adult brain cell body rind. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See Dora in Genome Data Viewer
    Location:
    17F1-17F2; 1-61 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18863950..18884075)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18757983..18778108)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ubiquitin specific protease 39 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fl(2)d-associated complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ago2 protects Drosophila siRNAs and microRNAs from target-directed degradation, even in the absence of 2'-O-methylation. Kingston ER, et al. RNA, 2021 Jun. PMID 33853897, Free PMC Article
    2. Par3/bazooka binds NICD and promotes notch signaling during Drosophila development. Wu J, et al. Dev Biol, 2024 Oct. PMID 38885804,
    3. Screening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA's role in regulating miR-999. Sheng P, et al. Nat Commun, 2023 Apr 13. PMID 37055443, Free PMC Article
    4. Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens. Godin SK, et al. Genetics, 2015 Apr. PMID 25659377, Free PMC Article
    5. The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation. Shi CY, et al. Science, 2020 Dec 18. PMID 33184237, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of miRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in target-directed miRNA degradation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dorado
    Names
    CG34401-PA
    CG34401-PB
    CG34401-PC
    Dora-PA
    Dora-PB
    Dora-PC
    pelado

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18863950..18884075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133108.3 → NP_573336.3  dorado, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573336.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      R9PY27

    2. NM_001370011.1 → NP_001356949.1  dorado, isoform C [Drosophila melanogaster]

      Status: REVIEWED

    3. NM_144236.3 → NP_652493.2  dorado, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652493.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A4D6K2F2, Q95ST9, Q9VWN9, R9PY27
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWN9.2 Q9VWN9

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