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    Polr2H RNA polymerase II, I and III subunit H [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40415, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr2Hprovided by FlyBase
    Official Full Name
    RNA polymerase II, I and III subunit Hprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037121
    Locus tag
    Dmel_CG11246
    See related
    AllianceGenome:FB:FBgn0037121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11246; Dmel\CG11246; Rpb8; RPB8
    Summary
    Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase I; and transcription by RNA polymerase II. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human POLR2H (RNA polymerase II, I and III subunit H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Polr2H in Genome Data Viewer
    Location:
    78E5-78E5; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21728932..21729694)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21722032..21722794)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assessment of the roles of Spt5-nucleic acid contacts in promoter proximal pausing of RNA polymerase II. Dollinger R, et al. J Biol Chem, 2023 Sep. PMID 37517697, Free PMC Article
    2. In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. Marygold SJ, et al. MicroPubl Biol, 2020 Oct 20. PMID 33274328, Free PMC Article
    3. Genes encoding Drosophila melanogaster RNA polymerase II general transcription factors: diversity in TFIIA and TFIID components contributes to gene-specific transcriptional regulation. Aoyagi N, et al. J Cell Biol, 2000 Jul 24. PMID 10908585, Free PMC Article
    4. A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. Kondo S, et al. Sci Signal, 2011 Jan 4. PMID 21205937, Free PMC Article
    5. Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. Tokusumi Y, et al. PLoS One, 2012. PMID 22911822, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase I activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription by RNA polymerase I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase II, I and III subunit H
    Names
    CG11246-PA
    Polr2H-PA
    Rpb8
    NP_649352.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21728932..21729694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141095.3 → NP_649352.1  RNA polymerase II, I and III subunit H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649352.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNZ3
      Related
      FBpp0078086
      Conserved Domains (1) summary
      smart00658
      Location:2 → 146
      RPOL8c; RNA polymerase subunit 8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNZ3 Q9VNZ3

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