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    CG6686 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34608, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6686provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032388
    Locus tag
    Dmel_CG6686
    See related
    AllianceGenome:FB:FBgn0032388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6686; SART1
    Summary
    Predicted to enable RNA binding activity. Involved in positive regulation of gene expression. Part of precatalytic spliceosome. Is expressed in spermatozoon. Orthologous to human SART1 (spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6686 in Genome Data Viewer
    Location:
    33B5-33B5; 2-45 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11984327..11988039, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11984327..11988039, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA::CR43314 Neighboring gene uncharacterized protein Neighboring gene bereft Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene zucchini Neighboring gene dim gamma-tubulin 2 Neighboring gene escl

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression. Taliaferro JM, et al. Genes Dev, 2013 Feb 15. PMID 23392611, Free PMC Article
    2. Brain Proteome of Drosophila melanogaster Is Enriched with Nuclear Proteins. Kuznetsova KG, et al. Biochemistry (Mosc), 2019 Jan. PMID 30927528
    3. Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA). Housden BE, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29183982, Free PMC Article
    4. Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity. Ma S, et al. Aging Cell, 2018 Aug. PMID 29671950, Free PMC Article
    5. Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments. Page RM, et al. J Neurosci, 2012 Dec 12. PMID 23238734, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of 5S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6686-PA
    CG6686-PB
    CG6686-PC
    NP_723700.1
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11984327..11988039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135685.4 → NP_609529.2  uncharacterized protein Dmel_CG6686, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609529.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKD8
      Related
      FBpp0088538
      Conserved Domains (1) summary
      pfam03343
      Location:273 → 912
      SART-1; SART-1 family

    2. NM_164978.3 → NP_723701.1  uncharacterized protein Dmel_CG6686, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723701.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHG4

    3. NM_164977.3 → NP_723700.1  uncharacterized protein Dmel_CG6686, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723700.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TU2
      Related
      FBpp0088537
      Conserved Domains (1) summary
      pfam03343
      Location:279 → 918
      SART-1; SART-1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHG4 E1JHG4
    Q8T064 Q8T064
    Q95TU2 Q95TU2
    Q9VKD8 Q9VKD8

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