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    mts microtubule star [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45959, updated on 27-Dec-2024

    Summary

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    Official Symbol
    mtsprovided by FlyBase
    Official Full Name
    microtubule starprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004177
    Locus tag
    Dmel_CG7109
    See related
    AllianceGenome:FB:FBgn0004177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5559; CG7109; Dmel\CG7109; DmPp2A-28D; dPP2A; dPP2A-C; ER2-6; l(2)02496; l(2)s5286; Mts; MTS; MTS/PP2A; PP2; pp2A; Pp2A; PP2a; PP2A; PP2a 28D; PP2A 28D; PP2A C; Pp2A-28D; PP2A-C; PP2A/MTS; PP2Ac; PP2AC; PP2A[C]; PP2A[[C]]
    Summary
    Enables phosphatase regulator activity and protein serine/threonine phosphatase activity. Involved in several processes, including generation of neurons; membraneless organelle assembly; and regulation of signal transduction. Located in cytoplasm. Part of FAR/SIN/STRIPAK complex. Colocalizes with centriole. Is expressed in several structures, including adult brain cell body rind; adult head; brain; female germline cell; and midgut. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha) and PPP2CB (protein phosphatase 2 catalytic subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mts in Genome Data Viewer
    Location:
    28D1-28D2; 2-29 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7827650..7833576)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7827650..7833576)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45008 Neighboring gene uncharacterized protein Neighboring gene Receptor of activated protein kinase C 1 Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase 1. Orgad S, et al. FEBS Lett, 1990 Nov 26. PMID 2175718
    2. Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos. Snaith HA, et al. J Cell Sci, 1996 Dec. PMID 9004035
    3. Molecular cloning and developmental expression of the catalytic and 65-kDa regulatory subunits of protein phosphatase 2A in Drosophila. Mayer-Jaekel RE, et al. Mol Biol Cell, 1992 Mar. PMID 1320961, Free PMC Article
    4. PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport. Tziortzouda P, et al. Acta Neuropathol, 2024 Feb 16. PMID 38363426, Free PMC Article
    5. Protein phosphatase 1 activity in Drosophila mutants with abnormalities in mitosis and chromosome condensation. Dombrádi V, et al. FEBS Lett, 1990 Nov 26. PMID 2175717

    See all (235) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein phosphatase 2A regulates blood cell proliferation and differentiation in Drosophila larval lymph glands.
      Title: Protein phosphatase 2A regulates blood cell proliferation and differentiation in Drosophila larval lymph glands.
    2. Multiple pools of PP2A regulate spindle assembly, kinetochore attachments and cohesion in Drosophila oocytes.
      Title: Multiple pools of PP2A regulate spindle assembly, kinetochore attachments and cohesion in Drosophila oocytes.
    3. Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.
      Title: Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.
    4. Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination.
      Title: Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination.
    5. Mob4/Cka/Mts functions as an intrinsic molecular switch coordinating Hippo and InR/PI3K/Akt pathways and enabling neural stem cells reactivation.
      Title: STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation.
    6. A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation.
      Title: A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation.
    7. Identify the dSTRIPAK PP2A complex as a major regulator of Hpo signaling. dSTRIPAK depletion leads to increased Hpo activation and repression of Yki target genes in vivo, suggesting this phosphatase complex prevents Hpo activation during development.
      Title: Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.
    8. findings suggest antagonistic roles for CK2 and PP2A during inhibitory Notch signaling.
      Title: Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and PP2A during Drosophila neurogenesis.
    9. PP2A suppresses aPKC signaling by promoting Par-6 dephosphorylation in neuroblasts, which uncovers a novel balancing mechanism for aPKC signaling in the regulation of asymmetric cell division.
      Title: Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions.
    10. mts is necessary for full activation of Hh signaling.
      Title: A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R7 cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in R8 cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in asymmetric neuroblast division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of epithelial cell polarity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Toll signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor guanylyl cyclase signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to light stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm HDA PubMed 
    part_of protein phosphatase type 2A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microtubule star
    Names
    CG7109-PA
    CG7109-PB
    CG7109-PC
    Microtubule-star
    PP2A catalytic subunit
    catalytic subunit C of type 2A protein phosphatase
    mts-PA
    mts-PB
    mts-PC
    phosphatase 2A catalytic subunit
    protein phosphatase 2A
    protein phosphatase 2A at 28D
    NP_001285724.1
    NP_001285725.1
    NP_476805.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7827650..7833576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298795.1 → NP_001285724.1  microtubule star, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285724.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23696, Q9VLW4
      UniProtKB/TrEMBL
      X2JDI1
      Conserved Domains (1) summary
      cd07415
      Location:9 → 293
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    2. NM_057457.4 → NP_476805.1  microtubule star, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476805.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23696, Q9VLW4
      UniProtKB/TrEMBL
      X2JDI1
      Related
      FBpp0079148
      Conserved Domains (1) summary
      cd07415
      Location:9 → 293
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    3. NM_001298796.1 → NP_001285725.1  microtubule star, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285725.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23696, Q9VLW4
      UniProtKB/TrEMBL
      X2JDI1
      Conserved Domains (1) summary
      cd07415
      Location:9 → 293
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23696.1 P23696
    X2JDI1 X2JDI1

    Gene LinkOut

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