U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Csrnp3 cysteine-serine-rich nuclear protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 77771, updated on 9-Dec-2024

    Summary

    Official Symbol
    Csrnp3provided by MGI
    Official Full Name
    cysteine-serine-rich nuclear protein 3provided by MGI
    Primary source
    MGI:MGI:1925021
    See related
    Ensembl:ENSMUSG00000044647 AllianceGenome:MGI:1925021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mbu1; Csnrp3; taip-2; CSRNP-3; A330102K23Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of apoptotic process and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; gonad; gut; liver; and spleen. Orthologous to human CSRNP3 (cysteine and serine rich nuclear protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 9.1), whole brain E14.5 (RPKM 8.2) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Csrnp3 in Genome Data Viewer
    Location:
    2 C1.3; 2 38.79 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (65675628..65866958)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (65845284..66036614)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm777 Neighboring gene sodium channel, voltage-gated, type II, alpha Neighboring gene STARR-seq mESC enhancer starr_04691 Neighboring gene STARR-seq mESC enhancer starr_04692 Neighboring gene STARR-seq mESC enhancer starr_04693 Neighboring gene predicted gene, 51432 Neighboring gene predicted gene, 52514 Neighboring gene STARR-seq mESC enhancer starr_04694 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_04695 Neighboring gene tetratricopeptide repeat domain 21B Neighboring gene STARR-positive B cell enhancer mm9_chr2:66094546-66094847

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cysteine/serine-rich nuclear protein 3
    Names
    TGF-beta induced apoptosis protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290665.1NP_001277594.1  cysteine/serine-rich nuclear protein 3 isoform b

      See identical proteins and their annotated locations for NP_001277594.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK158873, AL929230, AW492062
      Consensus CDS
      CCDS71060.1
      UniProtKB/Swiss-Prot
      P59055
      Related
      ENSMUSP00000135605.2, ENSMUST00000145598.9
      Conserved Domains (1) summary
      pfam16019
      Location:61278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    2. NM_001290666.1NP_001277595.1  cysteine/serine-rich nuclear protein 3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons, and it thus differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AL929230, AW492062, BC055701, BY297754
      UniProtKB/TrEMBL
      Q7TNU4
      Conserved Domains (2) summary
      pfam16019
      Location:35180
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
      cl00310
      Location:371416
      AIRC; AIR carboxylase
    3. NM_153409.5NP_700458.3  cysteine/serine-rich nuclear protein 3 isoform a

      See identical proteins and their annotated locations for NP_700458.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
      Source sequence(s)
      AK039150, AL929230, BY297754, EF210820
      Consensus CDS
      CCDS16074.2
      UniProtKB/Swiss-Prot
      A3F6Q4, P59055, Q8BUT9, Q8BYL1
      Related
      ENSMUSP00000117533.2, ENSMUST00000122912.8
      Conserved Domains (1) summary
      pfam16019
      Location:73290
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    4. NM_178634.2NP_848749.2  cysteine/serine-rich nuclear protein 3 isoform a

      See identical proteins and their annotated locations for NP_848749.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK082649, AL929230, BY297754, EF210820
      Consensus CDS
      CCDS16074.2
      UniProtKB/Swiss-Prot
      A3F6Q4, P59055, Q8BUT9, Q8BYL1
      Related
      ENSMUSP00000055719.4, ENSMUST00000053910.10
      Conserved Domains (1) summary
      pfam16019
      Location:73290
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      65675628..65866958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252233.1XP_030108093.1  cysteine/serine-rich nuclear protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A3F6Q4, P59055, Q8BUT9, Q8BYL1
      Conserved Domains (1) summary
      pfam16019
      Location:73290
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    2. XM_030252234.1XP_030108094.1  cysteine/serine-rich nuclear protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A3F6Q4, P59055, Q8BUT9, Q8BYL1
      Conserved Domains (1) summary
      pfam16019
      Location:73290
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    3. XM_030252235.1XP_030108095.1  cysteine/serine-rich nuclear protein 3 isoform X2

      Conserved Domains (1) summary
      pfam16019
      Location:61278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    4. XM_036162720.1XP_036018613.1  cysteine/serine-rich nuclear protein 3 isoform X2

      Conserved Domains (1) summary
      pfam16019
      Location:61278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    5. XM_030252237.1XP_030108097.1  cysteine/serine-rich nuclear protein 3 isoform X2

      Conserved Domains (1) summary
      pfam16019
      Location:61278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    6. XM_030252236.1XP_030108096.1  cysteine/serine-rich nuclear protein 3 isoform X2

      Conserved Domains (1) summary
      pfam16019
      Location:61278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus