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    fusl fuseless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33765, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fuslprovided by FlyBase
    Official Full Name
    fuselessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031702
    Locus tag
    Dmel_CG14021
    See related
    AllianceGenome:FB:FBgn0031702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14021; Dmel\CG14021; Fusl
    Summary
    Involved in clustering of voltage-gated calcium channels; neuromuscular synaptic transmission; and neuron-neuron synaptic transmission. Located in presynaptic membrane and terminal bouton. Is expressed in several structures, including adult head; retina; synaptic neuropil domain; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fusl in Genome Data Viewer
    Location:
    25D6-25D6; 2-16 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5330470..5338073, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5330470..5338073, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Turandot M Neighboring gene Acyl-CoA synthetase family member 2 Neighboring gene no mechanoreceptor potential C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In search of proteins that are important for synaptic functions in Drosophila visual system. Kim E, et al. J Neurogenet, 2012 Jun. PMID 22283835
    2. Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein. Long AA, et al. J Neurosci, 2008 Apr 2. PMID 18385325, Free PMC Article
    3. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Szuplewski S, et al. Genetics, 2001 Aug. PMID 11514451, Free PMC Article
    4. Genomic regulatory blocks underlie extensive microsynteny conservation in insects. Engström PG, et al. Genome Res, 2007 Dec. PMID 17989259, Free PMC Article
    5. Extracellular matrix and its receptors in Drosophila neural development. Broadie K, et al. Dev Neurobiol, 2011 Nov. PMID 21688401, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in clustering of voltage-gated calcium channels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clustering of voltage-gated calcium channels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron-neuron synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron-neuron synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fuseless
    Names
    CG14021-PA
    CG14021-PB
    CG14021-PC
    CG14021-PD
    CG14021-PE
    CG14021-PF
    fusl-PA
    fusl-PB
    fusl-PC
    fusl-PD
    fusl-PE
    fusl-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5330470..5338073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135079.6 → NP_608923.1  fuseless, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608923.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3S3
      Related
      FBpp0078712
      Conserved Domains (1) summary
      pfam15993
      Location:82 → 369
      Fuseless; Fuseless

    2. NM_164641.3 → NP_723080.1  fuseless, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723080.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3S3
      Conserved Domains (1) summary
      pfam15993
      Location:82 → 369
      Fuseless; Fuseless

    3. NM_164640.3 → NP_723079.1  fuseless, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723079.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3S3
      Related
      FBpp0078713
      Conserved Domains (1) summary
      pfam15993
      Location:82 → 369
      Fuseless; Fuseless

    4. NM_001258960.2 → NP_001245889.1  fuseless, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245889.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3S3
      Conserved Domains (1) summary
      pfam15993
      Location:82 → 369
      Fuseless; Fuseless

    5. NM_001258961.2 → NP_001245890.1  fuseless, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245890.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3S3
      Conserved Domains (1) summary
      pfam15993
      Location:82 → 369
      Fuseless; Fuseless

    6. NM_001298697.1 → NP_001285626.1  fuseless, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285626.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3S3
      Conserved Domains (1) summary
      pfam15993
      Location:82 → 369
      Fuseless; Fuseless
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3S3 Q7K3S3

    Gene LinkOut

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