Tfb5 Transcription factor B5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tfb5provided by FlyBase
Official Full Name: Transcription factor B5provided by FlyBase
Primary source: FLYBASE:FBgn0265968
Locus tag: Dmel_CG42373
See related: AllianceGenome:FB:FBgn0265968
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14037; CG42373; Dmel\CG42373; Dmp8; Dromel_CG31917_FBtr0079037_uORF; l(2)SH1279; l(2)SH2 1279; lincRNA.843; p8; TFB5; TFB5 (uORF); TTDA; uORF
Summary: Involved in nucleotide-excision repair; response to UV; and transcription by RNA polymerase II. Located in nucleus. Part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in photosensitive trichothiodystrophy 3. Orthologous to human GTF2H5 (general transcription factor IIH subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5009931..5010834, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5009931..5010834, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The Dmp8-Dmp18 bicistron messenger RNA enables unusual translation during cellular stress.
Title: The Dmp8-Dmp18 bicistron messenger RNA enables unusual translation during cellular stress.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in RNA polymerase II promoter clearance	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in nucleotide-excision repair	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair, preincision complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
involved_in transcription open complex formation at RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIH core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIH core complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIH core complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIH holo complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIH holo complex	IDA Inferred from Direct Assay more info	PubMed

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