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    Psma7 proteasome subunit alpha 7 [ Mus musculus (house mouse) ]

    Gene ID: 26444, updated on 9-Dec-2024

    Summary

    Official Symbol
    Psma7provided by MGI
    Official Full Name
    proteasome subunit alpha 7provided by MGI
    Primary source
    MGI:MGI:1347070
    See related
    Ensembl:ENSMUSG00000027566 AllianceGenome:MGI:1347070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C6-I
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in pancreas epithelium. Orthologous to human PSMA7 (proteasome 20S subunit alpha 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 74.2), CNS E14 (RPKM 56.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Psma7 in Genome Data Viewer
    Location:
    2 H4; 2 102.55 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179678160..179684257, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180036367..180042464, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921531C22 gene Neighboring gene STARR-seq mESC enhancer starr_06725 Neighboring gene STARR-positive B cell enhancer ABC_E7896 Neighboring gene LSM family member 14B Neighboring gene STARR-positive B cell enhancer ABC_E7897 Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 1 Neighboring gene mitochondrial ribosome associated GTPase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex, alpha-subunit complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    proteasome subunit alpha type-7
    Names
    alpha-4
    proteasome (prosome, macropain) subunit, alpha type 7
    proteasome subunit RC6-1
    proteasome subunit alpha-4
    NP_001276405.1
    NP_036099.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289476.1NP_001276405.1  proteasome subunit alpha type-7 isoform 2

      See identical proteins and their annotated locations for NP_001276405.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK146765, AL663067, BU841938, BY779773, CJ307624, DV049235
      UniProtKB/TrEMBL
      Q3THL2
      Related
      ENSMUST00000126021.8
      Conserved Domains (1) summary
      cl00467
      Location:1141
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    2. NM_011969.2NP_036099.1  proteasome subunit alpha type-7 isoform 1

      See identical proteins and their annotated locations for NP_036099.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK146765, BU841938, BY779773, CJ307624, DV049235
      Consensus CDS
      CCDS17166.1
      UniProtKB/Swiss-Prot
      Q9Z2U0
      UniProtKB/TrEMBL
      Q3TN31, Q3UIT9, Q542H2
      Related
      ENSMUSP00000029082.9, ENSMUST00000029082.9
      Conserved Domains (1) summary
      cd03755
      Location:3211
      proteasome_alpha_type_7; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      179678160..179684257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)