U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Wee1 WEE 1 homolog 1 (S. pombe) [ Mus musculus (house mouse) ]

    Gene ID: 22390, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wee1provided by MGI
    Official Full Name
    WEE 1 homolog 1 (S. pombe)provided by MGI
    Primary source
    MGI:MGI:103075
    See related
    Ensembl:ENSMUSG00000031016 AllianceGenome:MGI:103075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wee1A
    Summary
    Enables protein kinase activity. Acts upstream of or within several processes, including establishment of cell polarity; neuron projection morphogenesis; and peptidyl-tyrosine phosphorylation. Located in cytoplasm. Is expressed in several structures, including brain ventricular layer; early embryo; gut; humerus; and inferior colliculus. Orthologous to human WEE1 (WEE1 G2 checkpoint kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.3), placenta adult (RPKM 11.4) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Wee1 in Genome Data Viewer
    Location:
    7 E3; 7 57.7 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109721266..109742506)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110122059..110143299)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene importin 7 Neighboring gene STARR-seq mESC enhancer starr_19814 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene zinc finger protein 143 Neighboring gene STARR-seq mESC enhancer starr_19815 Neighboring gene STARR-positive B cell enhancer ABC_E293 Neighboring gene STARR-positive B cell enhancer ABC_E6584 Neighboring gene VISTA enhancer mm725 Neighboring gene STARR-seq mESC enhancer starr_19821 Neighboring gene STARR-positive B cell enhancer ABC_E8201 Neighboring gene predicted gene, 51505 Neighboring gene STARR-positive B cell enhancer ABC_E704 Neighboring gene SWA-70 protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation
    • Transgenic (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    wee1-like protein kinase
    Names
    WEE1 tyrosine kinase
    wee1A kinase
    NP_001341987.1
    NP_033542.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355058.1NP_001341987.1  wee1-like protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC147244
      Conserved Domains (1) summary
      cl21453
      Location:292518
      PKc_like; Protein Kinases, catalytic domain
    2. NM_009516.3NP_033542.2  wee1-like protein kinase isoform 1

      See identical proteins and their annotated locations for NP_033542.2

      Status: VALIDATED

      Source sequence(s)
      AK011212, AK039572, BY631896, CJ130595
      Consensus CDS
      CCDS21743.1
      UniProtKB/Swiss-Prot
      P47810, Q9EPL7
      Related
      ENSMUSP00000033326.9, ENSMUST00000033326.10
      Conserved Domains (2) summary
      cd14138
      Location:292567
      PTKc_Wee1a; Catalytic domain of the Protein Tyrosine Kinase, Wee1a
      pfam00069
      Location:298568
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      109721266..109742506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)