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    Aqp5 aquaporin 5 [ Mus musculus (house mouse) ]

    Gene ID: 11830, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aqp5provided by MGI
    Official Full Name
    aquaporin 5provided by MGI
    Primary source
    MGI:MGI:106215
    See related
    Ensembl:ENSMUSG00000044217 AllianceGenome:MGI:106215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity and water channel activity. Acts upstream of or within camera-type eye morphogenesis; saliva secretion; and water transport. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and microvillus. Is expressed in several structures, including exocrine system; lung; nucleus pulposus; oocyte; and sensory organ. Used to study dry eye syndrome. Human ortholog(s) of this gene implicated in Bothnian type palmoplantar keratoderma. Orthologous to human AQP5 (aquaporin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 187.0), mammary gland adult (RPKM 72.8) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Aqp5 in Genome Data Viewer
    Location:
    15 F1; 15 56.13 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99488909..99492710)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99591028..99594829)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5808 Neighboring gene predicted gene, 34765 Neighboring gene STARR-seq mESC enhancer starr_39713 Neighboring gene aquaporin 2 Neighboring gene aquaporin 6 Neighboring gene Rac GTPase-activating protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr15:99481947-99482248

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables water channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables water channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables water channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in carbon dioxide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in carbon dioxide transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carbon dioxide transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular hypotonic response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular hypotonic response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in odontogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pancreatic juice secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within saliva secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in water transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within water transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in water transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in water transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within water transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009701.4NP_033831.1  aquaporin-5

      See identical proteins and their annotated locations for NP_033831.1

      Status: VALIDATED

      Source sequence(s)
      AC139317, AK009302
      Consensus CDS
      CCDS27823.1
      UniProtKB/Swiss-Prot
      Q545H1, Q9WTY4
      UniProtKB/TrEMBL
      B2RWZ5
      Related
      ENSMUSP00000127611.2, ENSMUST00000169082.3
      Conserved Domains (1) summary
      pfam00230
      Location:4221
      MIP; Major intrinsic protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99488909..99492710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)