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    Txnrd2 thioredoxin reductase 2 [ Mus musculus (house mouse) ]

    Gene ID: 26462, updated on 9-Dec-2024

    Summary

    Official Symbol
    Txnrd2provided by MGI
    Official Full Name
    thioredoxin reductase 2provided by MGI
    Primary source
    MGI:MGI:1347023
    See related
    Ensembl:ENSMUSG00000075704 AllianceGenome:MGI:1347023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TGR; Tr3; Trxr2; Trxrd2; ESTM573010
    Summary
    The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2017]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 41.1), liver E14 (RPKM 39.1) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Txnrd2 in Genome Data Viewer
    Location:
    16 A3; 16 11.41 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18245167..18297823)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18426417..18479073)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene STARR-seq mESC enhancer starr_40280 Neighboring gene predicted gene 15764 Neighboring gene catechol-O-methyltransferase Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18460133-18460376 Neighboring gene STARR-seq mESC enhancer starr_40284 Neighboring gene STARR-seq mESC enhancer starr_40285 Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 1-like Neighboring gene VISTA enhancer mm321 Neighboring gene predicted gene, 35369 Neighboring gene T-box 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thioredoxin-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thioredoxin-disulfide reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thioredoxin-disulfide reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell redox homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxygen radical TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    thioredoxin reductase 2, mitochondrial
    Names
    TR beta
    thioredoxin reductase TR3
    NP_001340072.1
    NP_038739.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353143.1NP_001340072.1  thioredoxin reductase 2, mitochondrial isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon in the 3' region compared to variant 1. The resulting shorter isoform (2) is missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AB027566, AF412308, BF465261
      Consensus CDS
      CCDS88895.1
      UniProtKB/TrEMBL
      A0A0U1RPV8
      Related
      ENSMUSP00000146143.3, ENSMUST00000206606.3
      Conserved Domains (1) summary
      cl27343
      Location:43496
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
    2. NM_013711.3NP_038739.2  thioredoxin reductase 2, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_038739.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB027566, BF465261
      Consensus CDS
      CCDS79434.1
      UniProtKB/TrEMBL
      A0A0M3HEQ0
      Related
      ENSMUSP00000111269.4, ENSMUST00000115606.9
      Conserved Domains (4) summary
      TIGR01438
      Location:43527
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:223289
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:399508
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
      cl21454
      Location:4370
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      18245167..18297823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)