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    Adrb2 adrenergic receptor, beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 11555, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adrb2provided by MGI
    Official Full Name
    adrenergic receptor, beta 2provided by MGI
    Primary source
    MGI:MGI:87938
    See related
    Ensembl:ENSMUSG00000045730 AllianceGenome:MGI:87938
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Badm; Gpcr7; Adrb-2
    Summary
    This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 adrenergic receptor which is activated by catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]
    Orthologs
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    Genomic context

    See Adrb2 in Genome Data Viewer
    Location:
    18 E1; 18 35.1 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (62310784..62313052, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62177713..62179981, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41750 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:62334464-62334573 Neighboring gene STARR-seq mESC enhancer starr_44769 Neighboring gene STARR-seq mESC enhancer starr_44770 Neighboring gene predicted gene, 36003 Neighboring gene predicted gene 9949 Neighboring gene predicted gene, 36124 Neighboring gene STARR-seq mESC enhancer starr_44772 Neighboring gene 5 hydroxytryptamine (serotonin) receptor 4 Neighboring gene predicted gene, 36316

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables B2 bradykinin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenylate cyclase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta2-adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta2-adrenergic receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta2-adrenergic receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables norepinephrine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables norepinephrine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables norepinephrine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables potassium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor-receptor interaction ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in AMPA selective glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within brown fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to amyloid-beta IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diaphragm contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within diet induced thermogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heat generation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of smooth muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of AMPA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagosome maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cAMP/PKA signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of calcium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of lipophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mini excitatory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of skeletal muscle tissue growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of the force of heart contraction by epinephrine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of systemic arterial blood pressure by norepinephrine-epinephrine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to catecholamine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to cold IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of smooth muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal dense core vesicle EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in neuronal dense core vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    beta-2 adrenergic receptor
    Names
    beta 2-AR
    beta-2 adrenoceptor
    beta-2 adrenoreceptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007420.3NP_031446.2  beta-2 adrenergic receptor

      See identical proteins and their annotated locations for NP_031446.2

      Status: REVIEWED

      Source sequence(s)
      AC124430, BB844430, BC032883
      Consensus CDS
      CCDS29289.1
      UniProtKB/Swiss-Prot
      P18762, Q8BH38
      Related
      ENSMUSP00000062256.4, ENSMUST00000053640.5
      Conserved Domains (2) summary
      pfam00001
      Location:50326
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:48340
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      62310784..62313052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)