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    Strada STE20-related kinase adaptor alpha [ Mus musculus (house mouse) ]

    Gene ID: 72149, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stradaprovided by MGI
    Official Full Name
    STE20-related kinase adaptor alphaprovided by MGI
    Primary source
    MGI:MGI:1919399
    See related
    Ensembl:ENSMUSG00000069631 AllianceGenome:MGI:1919399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610019A05Rik; 6030402H20Rik; E130112C09Rik
    Summary
    Predicted to enable kinase binding activity and protein serine/threonine kinase activator activity. Predicted to contribute to protein serine/threonine kinase activity. Acts upstream of or within activation of protein kinase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of intracellular protein-containing complex and serine/threonine protein kinase complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular zone; cortical plate; and thymus primordium. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to human STRADA (STE20 related adaptor alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 47.7), frontal lobe adult (RPKM 14.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Strada in Genome Data Viewer
    Location:
    11 E1; 11 68.89 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106053739..106084460, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106162974..106193634, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 3 Neighboring gene STARR-seq mESC enhancer starr_30916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106020710-106020950 Neighboring gene predicted gene 10840 Neighboring gene LIM domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E7078 Neighboring gene STARR-positive B cell enhancer ABC_E739 Neighboring gene coiled-coil domain containing 47 Neighboring gene STARR-positive B cell enhancer ABC_E5285 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106078089-106078198 Neighboring gene STARR-positive B cell enhancer ABC_E7080 Neighboring gene DEAD box helicase 42 Neighboring gene STARR-positive B cell enhancer ABC_E5286 Neighboring gene FtsJ RNA 2'-O-methyltransferase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G1 to G0 transition IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_negative_effect G1 to G0 transition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of intracellular protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of intracellular protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of serine/threonine protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of serine/threonine protein kinase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of serine/threonine protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    STE20-related kinase adapter protein alpha
    Names
    STE20-related adapter protein
    STRAD alpha
    protein kinase LYK5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252448.2NP_001239377.1  STE20-related kinase adapter protein alpha isoform 1

      See identical proteins and their annotated locations for NP_001239377.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL596331
      Consensus CDS
      CCDS56816.1
      UniProtKB/Swiss-Prot
      Q3UUJ4, Q6VEU7, Q9D0G8
      Related
      ENSMUSP00000007444.8, ENSMUST00000007444.14
      Conserved Domains (1) summary
      cd08227
      Location:70396
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    2. NM_001252449.2NP_001239378.1  STE20-related kinase adapter protein alpha isoform 3

      See identical proteins and their annotated locations for NP_001239378.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons in the 5' coding region and a segment in the 3' coding region, compared to variant 1. The reading frame is not affected and the resulting isoform (3) lacks a segment in the N-terminal region and a segment in the C-terminal region, compared to isoform 1.
      Source sequence(s)
      AL596331
      UniProtKB/Swiss-Prot
      Q3UUJ4
      Conserved Domains (2) summary
      smart00220
      Location:32334
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:33347
      PKc_like; Protein Kinases, catalytic domain
    3. NM_028126.4NP_082402.1  STE20-related kinase adapter protein alpha isoform 2

      See identical proteins and their annotated locations for NP_082402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive exons in the 5' coding region, compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AL596331
      Consensus CDS
      CCDS25550.1
      UniProtKB/Swiss-Prot
      Q3UUJ4
      Related
      ENSMUSP00000099361.4, ENSMUST00000103072.10
      Conserved Domains (1) summary
      cd08227
      Location:33359
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106053739..106084460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534293.4XP_006534356.1  STE20-related kinase adapter protein alpha isoform X2

      Conserved Domains (1) summary
      cd08227
      Location:62388
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    2. XM_011249270.1XP_011247572.1  STE20-related kinase adapter protein alpha isoform X1

      See identical proteins and their annotated locations for XP_011247572.1

      UniProtKB/Swiss-Prot
      Q3UUJ4, Q6VEU7, Q9D0G8
      Related
      ENSMUST00000122989.2
      Conserved Domains (1) summary
      cd08227
      Location:70396
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    3. XM_006534294.5XP_006534357.1  STE20-related kinase adapter protein alpha isoform X3

      Conserved Domains (1) summary
      cd08227
      Location:41367
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    4. XM_006534297.5XP_006534360.1  STE20-related kinase adapter protein alpha isoform X5

      See identical proteins and their annotated locations for XP_006534360.1

      Conserved Domains (1) summary
      cd08227
      Location:13339
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    5. XM_006534296.5XP_006534359.1  STE20-related kinase adapter protein alpha isoform X5

      See identical proteins and their annotated locations for XP_006534359.1

      Conserved Domains (1) summary
      cd08227
      Location:13339
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    6. XM_006534295.3XP_006534358.1  STE20-related kinase adapter protein alpha isoform X4

      See identical proteins and their annotated locations for XP_006534358.1

      UniProtKB/Swiss-Prot
      Q3UUJ4
      Conserved Domains (1) summary
      cd08227
      Location:33359
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    7. XM_030246360.2XP_030102220.1  STE20-related kinase adapter protein alpha isoform X3

      Conserved Domains (1) summary
      cd08227
      Location:41367
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha