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    Dcbld2 discoidin, CUB and LCCL domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 73379, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dcbld2provided by MGI
    Official Full Name
    discoidin, CUB and LCCL domain containing 2provided by MGI
    Primary source
    MGI:MGI:1920629
    See related
    Ensembl:ENSMUSG00000035107 AllianceGenome:MGI:1920629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Esdn; CLCP1; 1700055P21Rik
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in negative regulation of cell growth and wound healing. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human DCBLD2 (discoidin, CUB and LCCL domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 10.6), CNS E11.5 (RPKM 10.5) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dcbld2 in Genome Data Viewer
    Location:
    16 C1.2; 16 34.52 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (58228789..58304013)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (58408535..58469745)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57639 Neighboring gene STARR-seq mESC enhancer starr_41093 Neighboring gene predicted gene, 41463 Neighboring gene STARR-seq mESC enhancer starr_41094 Neighboring gene STARR-seq mESC enhancer starr_41095 Neighboring gene RIKEN cDNA 4930461C15 gene Neighboring gene STARR-positive B cell enhancer ABC_E1928 Neighboring gene STARR-seq mESC enhancer starr_41096 Neighboring gene STARR-positive B cell enhancer ABC_E3167 Neighboring gene STARR-positive B cell enhancer ABC_E8639 Neighboring gene STARR-positive B cell enhancer ABC_E3168 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 6 Neighboring gene STARR-seq mESC enhancer starr_41097 Neighboring gene STARR-seq mESC enhancer starr_41098 Neighboring gene predicted gene, 20942 Neighboring gene ferritin domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    discoidin, CUB and LCCL domain-containing protein 2
    Names
    endothelial and smooth muscle cell-derived neuropilin-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356484.1NP_001343413.1  discoidin, CUB and LCCL domain-containing protein 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT027564
      Conserved Domains (3) summary
      cd00041
      Location:69183
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:293445
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl02694
      Location:190272
      LCCL; LCCL domain
    2. NM_028523.3NP_082799.2  discoidin, CUB and LCCL domain-containing protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_082799.2

      Status: VALIDATED

      Source sequence(s)
      AK043915, AK051889, AK052189, BC066097, CAAA01184608
      Consensus CDS
      CCDS28229.1
      UniProtKB/Swiss-Prot
      A6X950, Q8BKI4, Q91ZV3
      Related
      ENSMUSP00000039915.8, ENSMUST00000046663.8
      Conserved Domains (4) summary
      smart00231
      Location:288446
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:69183
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:293445
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl02694
      Location:190272
      LCCL; LCCL domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      58228789..58304013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160148.1XP_036016041.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X1

      Conserved Domains (3) summary
      cd00041
      Location:69183
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl25480
      Location:293400
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl02694
      Location:190272
      LCCL; LCCL domain
    2. XM_036160149.1XP_036016042.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X2

      Conserved Domains (3) summary
      cd00041
      Location:69183
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl25480
      Location:293400
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl02694
      Location:190272
      LCCL; LCCL domain
    3. XM_011246022.3XP_011244324.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X3

      Conserved Domains (3) summary
      cd00057
      Location:217369
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl00049
      Location:66107
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl02694
      Location:114196
      LCCL; LCCL domain

    RNA

    1. XR_004939243.1 RNA Sequence

    2. XR_004939244.1 RNA Sequence

    3. XR_004939245.1 RNA Sequence

    4. XR_004939246.1 RNA Sequence

    5. XR_004939247.1 RNA Sequence

    6. XR_004939248.1 RNA Sequence