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    Fap fibroblast activation protein [ Mus musculus (house mouse) ]

    Gene ID: 14089, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fapprovided by MGI
    Official Full Name
    fibroblast activation proteinprovided by MGI
    Primary source
    MGI:MGI:109608
    See related
    Ensembl:ENSMUSG00000000392 AllianceGenome:MGI:109608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SIMP
    Summary
    This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available. [provided by RefSeq, Apr 2013]
    Expression
    Biased expression in limb E14.5 (RPKM 7.4), mammary gland adult (RPKM 2.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fap in Genome Data Viewer
    Location:
    2 C1.3; 2 35.85 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (62331280..62404365, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (62500936..62575509, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04641 Neighboring gene STARR-positive B cell enhancer ABC_E3379 Neighboring gene STARR-positive B cell enhancer ABC_E2037 Neighboring gene STARR-positive B cell enhancer ABC_E5926 Neighboring gene STARR-positive B cell enhancer ABC_E5927 Neighboring gene predicted gene 13561 Neighboring gene Gcg promoter region Neighboring gene glucagon Neighboring gene STARR-seq mESC enhancer starr_04642 Neighboring gene interferon induced with helicase C domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E10108 Neighboring gene predicted gene, 39839 Neighboring gene STARR-positive B cell enhancer ABC_E4458 Neighboring gene STARR-positive B cell enhancer ABC_E1006 Neighboring gene STARR-seq mESC enhancer starr_04644 Neighboring gene STARR-seq mESC enhancer starr_04645 Neighboring gene soc-2 (suppressor of clear) homolog pseudogene Neighboring gene grancalcin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dipeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dipeptidyl-peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in melanocyte apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in melanocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell proliferation involved in contact inhibition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extracellular matrix disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extracellular matrix organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis involved in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis involved in protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of collagen catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of peptidase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of peptidase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    prolyl endopeptidase FAP
    Names
    FAPalpha
    dipeptidyl peptidase FAP
    fibroblast activation protein alpha
    gelatine degradation protease FAP
    integral membrane serine protease
    post-proline cleaving enzyme
    seprase
    serine integral membrane protease
    surface-expressed protease
    NP_032012.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007986.3NP_032012.1  prolyl endopeptidase FAP

      See identical proteins and their annotated locations for NP_032012.1

      Status: REVIEWED

      Source sequence(s)
      AL928576
      Consensus CDS
      CCDS16067.1
      UniProtKB/Swiss-Prot
      P97321
      UniProtKB/TrEMBL
      A0A172Q394, G3UXR2
      Related
      ENSMUSP00000099793.4, ENSMUST00000102732.10
      Conserved Domains (3) summary
      pfam00326
      Location:553757
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:106473
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      pfam18811
      Location:3757
      DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      62331280..62404365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)