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    Ufc1 ubiquitin-fold modifier conjugating enzyme 1 [ Mus musculus (house mouse) ]

    Gene ID: 66155, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ufc1provided by MGI
    Official Full Name
    ubiquitin-fold modifier conjugating enzyme 1provided by MGI
    Primary source
    MGI:MGI:1913405
    See related
    Ensembl:ENSMUSG00000062963 AllianceGenome:MGI:1913405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM29; 1110021H02Rik
    Summary
    Enables UFM1 conjugating enzyme activity. Involved in protein ufmylation and regulation of type II interferon production. Is expressed in chondrocranium and liver. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spasticity and poor growth. Orthologous to human UFC1 (ubiquitin-fold modifier conjugating enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 26.0), placenta adult (RPKM 25.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ufc1 in Genome Data Viewer
    Location:
    1 H3; 1 79.31 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171116137..171122575, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171288564..171295002, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protoporphyrinogen oxidase Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211225-173211526 Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211857-173212158 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene STARR-seq mESC enhancer starr_03026 Neighboring gene STARR-seq mESC enhancer starr_03027 Neighboring gene ribosomal protein L27, pseudogene 1 Neighboring gene predicted gene, 25151

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UFM1 conjugating enzyme activity PubMed 
    enables UFM1 conjugating enzyme activity  
    enables UFM1 transferase activity  
    Process Evidence Code Pubs
    involved_in brain development  
    involved_in brain development  
    involved_in protein K69-linked ufmylation  
    involved_in protein K69-linked ufmylation  
    involved_in protein ufmylation PubMed 
    acts_upstream_of_or_within protein ufmylation PubMed 
    involved_in protein ufmylation  
    involved_in regulation of type II interferon production PubMed 
    involved_in response to endoplasmic reticulum stress  
    acts_upstream_of_or_within response to endoplasmic reticulum stress PubMed 
    involved_in response to endoplasmic reticulum stress  
    involved_in response to endoplasmic reticulum stress  
    involved_in reticulophagy  
    involved_in reticulophagy  
    involved_in reticulophagy  

    General protein information

    Preferred Names
    ubiquitin-fold modifier-conjugating enzyme 1
    Names
    Ufm1-conjugating enzyme 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360931.1NP_001347860.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC087229
      Consensus CDS
      CCDS15488.1
      UniProtKB/Swiss-Prot
      Q9CR09
      Related
      ENSMUSP00000106933.4, ENSMUST00000111302.4
      Conserved Domains (1) summary
      pfam08694
      Location:6160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
    2. NM_001360932.1NP_001347861.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC087229, AI596556, BE652094
      Consensus CDS
      CCDS15488.1
      UniProtKB/Swiss-Prot
      Q9CR09
      Conserved Domains (1) summary
      pfam08694
      Location:6160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
    3. NM_001360933.1NP_001347862.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC087229, AI596556
      Conserved Domains (1) summary
      pfam08694
      Location:680
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
    4. NM_025388.3NP_079664.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform a

      See identical proteins and their annotated locations for NP_079664.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC087229, AK003897
      Consensus CDS
      CCDS15488.1
      UniProtKB/Swiss-Prot
      Q9CR09
      Related
      ENSMUSP00000078914.3, ENSMUST00000080001.9
      Conserved Domains (1) summary
      pfam08694
      Location:6160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171116137..171122575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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