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    Grb14 growth factor receptor bound protein 14 [ Mus musculus (house mouse) ]

    Gene ID: 50915, updated on 9-Dec-2024

    Summary

    Official Symbol
    Grb14provided by MGI
    Official Full Name
    growth factor receptor bound protein 14provided by MGI
    Primary source
    MGI:MGI:1355324
    See related
    Ensembl:ENSMUSG00000026888 AllianceGenome:MGI:1355324
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables protein-macromolecule adaptor activity. Predicted to be involved in insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; and negative regulation of meiotic cell cycle process involved in oocyte maturation. Predicted to act upstream of or within signal transduction. Predicted to be located in endosome. Predicted to be active in cytoplasm and plasma membrane. Is expressed in forebrain; ganglia; male reproductive gland or organ; and nucleus pulposus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GRB14 (growth factor receptor bound protein 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 19.5), ovary adult (RPKM 12.9) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Grb14 in Genome Data Viewer
    Location:
    2 C1.3; 2 38.35 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (64742820..64853143, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (64912476..65022766, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Parkinson disease 7 domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04664 Neighboring gene predicted gene 13578 Neighboring gene STARR-seq mESC enhancer starr_04666 Neighboring gene STARR-seq mESC enhancer starr_04667 Neighboring gene STARR-positive B cell enhancer mm9_chr2:64959532-64959832 Neighboring gene Cobl-like 1 Neighboring gene predicted gene, 57691 Neighboring gene STARR-seq mESC enhancer starr_04668 Neighboring gene STARR-positive B cell enhancer ABC_E4459 Neighboring gene STARR-seq mESC enhancer starr_04669 Neighboring gene STARR-seq mESC enhancer starr_04670 Neighboring gene predicted gene 13594

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    growth factor receptor-bound protein 14
    Names
    GRB14 adapter protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412538.1NP_001399467.1  growth factor receptor-bound protein 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL928703, AL929129
    2. NM_001412539.1NP_001399468.1  growth factor receptor-bound protein 14 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL928703, AL929129
    3. NM_001412540.1NP_001399469.1  growth factor receptor-bound protein 14 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL928703, AL929129
    4. NM_016719.2NP_057928.1  growth factor receptor-bound protein 14 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL928703, AL929129
      Consensus CDS
      CCDS16071.1
      UniProtKB/Swiss-Prot
      Q3UI77, Q8VDI2, Q9CR03, Q9JLM9
      UniProtKB/TrEMBL
      A2ASX2
      Related
      ENSMUSP00000028252.8, ENSMUST00000028252.14
      Conserved Domains (5) summary
      cd01787
      Location:104188
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10414
      Location:431538
      SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
      cd01259
      Location:228349
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam00169
      Location:233339
      PH; PH domain
      pfam08947
      Location:368412
      BPS; BPS (Between PH and SH2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      64742820..64853143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)