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    Mtg2 mitochondrial ribosome associated GTPase 2 [ Mus musculus (house mouse) ]

    Gene ID: 52856, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mtg2provided by MGI
    Official Full Name
    mitochondrial ribosome associated GTPase 2provided by MGI
    Primary source
    MGI:MGI:106565
    See related
    Ensembl:ENSMUSG00000039069 AllianceGenome:MGI:106565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtpbp5; D2Bwg0647e; 1810011P19Rik; 2900056P18Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in regulation of mitochondrial translation and regulation of respiratory system process. Located in mitochondrion. Orthologous to human MTG2 (mitochondrial ribosome associated GTPase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.5), CNS E14 (RPKM 5.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mtg2 in Genome Data Viewer
    Location:
    2 H4; 2 102.59 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179712366..179727695)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180070573..180085902)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proteasome subunit alpha 7 Neighboring gene STARR-positive B cell enhancer ABC_E7897 Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:179830439-179830640 Neighboring gene histamine receptor H3 Neighboring gene predicted gene, 46782

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of respiratory system process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    mitochondrial ribosome-associated GTPase 2
    Names
    GTP binding protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083328.1NP_001076797.1  mitochondrial ribosome-associated GTPase 2

      See identical proteins and their annotated locations for NP_001076797.1

      Status: VALIDATED

      Source sequence(s)
      BC028465, BF012021, BY726952, DT929445
      Consensus CDS
      CCDS38374.1
      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    2. NM_001083329.1NP_001076798.1  mitochondrial ribosome-associated GTPase 2

      See identical proteins and their annotated locations for NP_001076798.1

      Status: VALIDATED

      Source sequence(s)
      AW647214, BC028465, BY726952, DT929445
      Consensus CDS
      CCDS38374.1
      UniProtKB/TrEMBL
      A2AFK4
      Related
      ENSMUSP00000104529.2, ENSMUST00000108901.8
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    3. NM_028422.1NP_082698.1  mitochondrial ribosome-associated GTPase 2

      See identical proteins and their annotated locations for NP_082698.1

      Status: VALIDATED

      Source sequence(s)
      BC028465, BY726952, CX210755, DT929445
      Consensus CDS
      CCDS38374.1
      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    4. NM_181424.3NP_852089.2  mitochondrial ribosome-associated GTPase 2

      See identical proteins and their annotated locations for NP_852089.2

      Status: VALIDATED

      Source sequence(s)
      BC028465, BY726952, DT929445
      Consensus CDS
      CCDS38374.1
      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      179712366..179727695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162385.1XP_036018278.1  mitochondrial ribosome-associated GTPase 2 isoform X8

      Conserved Domains (1) summary
      TIGR02729
      Location:112271
      Obg_CgtA; Obg family GTPase CgtA
    2. XM_036162375.1XP_036018268.1  mitochondrial ribosome-associated GTPase 2 isoform X2

      Conserved Domains (1) summary
      TIGR02729
      Location:142417
      Obg_CgtA; Obg family GTPase CgtA
    3. XM_036162378.1XP_036018271.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    4. XM_030251869.2XP_030107729.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    5. XM_036162380.1XP_036018273.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    6. XM_036162389.1XP_036018282.1  mitochondrial ribosome-associated GTPase 2 isoform X11

      Conserved Domains (1) summary
      cl38936
      Location:117229
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    7. XM_006500675.2XP_006500738.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      See identical proteins and their annotated locations for XP_006500738.1

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    8. XM_030251872.2XP_030107732.1  mitochondrial ribosome-associated GTPase 2 isoform X8

      Conserved Domains (1) summary
      TIGR02729
      Location:112271
      Obg_CgtA; Obg family GTPase CgtA
    9. XM_030251865.2XP_030107725.1  mitochondrial ribosome-associated GTPase 2 isoform X2

      Conserved Domains (1) summary
      TIGR02729
      Location:142417
      Obg_CgtA; Obg family GTPase CgtA
    10. XM_017319125.2XP_017174614.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    11. XM_030251871.2XP_030107731.1  mitochondrial ribosome-associated GTPase 2 isoform X7

      Conserved Domains (1) summary
      TIGR02729
      Location:52327
      Obg_CgtA; Obg family GTPase CgtA
    12. XM_011239951.2XP_011238253.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      See identical proteins and their annotated locations for XP_011238253.1

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    13. XM_030251873.2XP_030107733.1  mitochondrial ribosome-associated GTPase 2 isoform X8

      Conserved Domains (1) summary
      TIGR02729
      Location:112271
      Obg_CgtA; Obg family GTPase CgtA
    14. XM_006500676.2XP_006500739.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      See identical proteins and their annotated locations for XP_006500739.1

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    15. XM_030251875.2XP_030107735.1  mitochondrial ribosome-associated GTPase 2 isoform X10

      UniProtKB/TrEMBL
      I6L986
      Conserved Domains (1) summary
      pfam01018
      Location:107222
      GTP1_OBG; GTP1/OBG
    16. XM_036162377.1XP_036018270.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    17. XM_036162376.1XP_036018269.1  mitochondrial ribosome-associated GTPase 2 isoform X2

      Conserved Domains (1) summary
      TIGR02729
      Location:142417
      Obg_CgtA; Obg family GTPase CgtA
    18. XM_036162383.1XP_036018276.1  mitochondrial ribosome-associated GTPase 2 isoform X8

      Conserved Domains (1) summary
      TIGR02729
      Location:112271
      Obg_CgtA; Obg family GTPase CgtA
    19. XM_036162387.1XP_036018280.1  mitochondrial ribosome-associated GTPase 2 isoform X10

      UniProtKB/TrEMBL
      I6L986
      Related
      ENSMUSP00000139273.2, ENSMUST00000184862.8
      Conserved Domains (1) summary
      pfam01018
      Location:107222
      GTP1_OBG; GTP1/OBG
    20. XM_036162388.1XP_036018281.1  mitochondrial ribosome-associated GTPase 2 isoform X11

      Conserved Domains (1) summary
      cl38936
      Location:117229
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    21. XM_006500672.2XP_006500735.1  mitochondrial ribosome-associated GTPase 2 isoform X2

      See identical proteins and their annotated locations for XP_006500735.1

      Conserved Domains (1) summary
      TIGR02729
      Location:142417
      Obg_CgtA; Obg family GTPase CgtA
    22. XM_036162384.1XP_036018277.1  mitochondrial ribosome-associated GTPase 2 isoform X8

      Conserved Domains (1) summary
      TIGR02729
      Location:112271
      Obg_CgtA; Obg family GTPase CgtA
    23. XM_036162382.1XP_036018275.1  mitochondrial ribosome-associated GTPase 2 isoform X7

      Conserved Domains (1) summary
      TIGR02729
      Location:52327
      Obg_CgtA; Obg family GTPase CgtA
    24. XM_036162379.1XP_036018272.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    25. XM_036162390.1XP_036018283.1  mitochondrial ribosome-associated GTPase 2 isoform X11

      Conserved Domains (1) summary
      cl38936
      Location:117229
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    26. XM_030251868.2XP_030107728.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112387
      Obg_CgtA; Obg family GTPase CgtA
    27. XM_017319124.1XP_017174613.1  mitochondrial ribosome-associated GTPase 2 isoform X1

      Conserved Domains (1) summary
      TIGR02729
      Location:222497
      Obg_CgtA; Obg family GTPase CgtA
    28. XM_006500674.2XP_006500737.1  mitochondrial ribosome-associated GTPase 2 isoform X3

      Conserved Domains (1) summary
      TIGR02729
      Location:222381
      Obg_CgtA; Obg family GTPase CgtA
    29. XM_006500677.3XP_006500740.1  mitochondrial ribosome-associated GTPase 2 isoform X5

      Conserved Domains (1) summary
      pfam01018
      Location:217332
      GTP1_OBG; GTP1/OBG
    30. XM_036162386.1XP_036018279.1  mitochondrial ribosome-associated GTPase 2 isoform X9

      Conserved Domains (1) summary
      pfam01018
      Location:217264
      GTP1_OBG; GTP1/OBG
    31. XM_036162381.1XP_036018274.1  mitochondrial ribosome-associated GTPase 2 isoform X6

      Conserved Domains (1) summary
      cl38936
      Location:227339
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_003953669.1 RNA Sequence

    2. XR_004940655.1 RNA Sequence

    3. XR_001783146.2 RNA Sequence

    4. XR_003953667.2 RNA Sequence

    5. XR_003953670.2 RNA Sequence

    6. XR_003953668.2 RNA Sequence

    7. XR_004940653.1 RNA Sequence

    8. XR_004940654.1 RNA Sequence

    9. XR_375400.3 RNA Sequence

    10. XR_003953666.1 RNA Sequence