U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rec8 REC8 meiotic recombination protein [ Mus musculus (house mouse) ]

    Gene ID: 56739, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rec8provided by MGI
    Official Full Name
    REC8 meiotic recombination proteinprovided by MGI
    Primary source
    MGI:MGI:1929645
    See related
    Ensembl:ENSMUSG00000002324 AllianceGenome:MGI:1929645
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mrec; Rec8L1
    Summary
    Predicted to enable chromatin binding activity. Acts upstream of or within several processes, including germ cell development; meiosis I; and seminiferous tubule development. Located in kinetochore; lateral element; and male germ cell nucleus. Part of meiotic cohesin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human REC8 (REC8 meiotic recombination protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 25.9), duodenum adult (RPKM 18.4) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rec8 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55855459..55862852)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55618002..55625395)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 31 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56222707-56223021 Neighboring gene interferon regulatory factor 9 Neighboring gene importin 4 Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene testis-specific serine kinase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral element IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of meiotic cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of meiotic cohesin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    meiotic recombination protein REC8 homolog
    Names
    REC8-like 1
    cohesin Rec8p
    meiotic cohesion Rec8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360389.1NP_001347318.1  meiotic recombination protein REC8 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC174678, BC052155
      Conserved Domains (1) summary
      pfam04824
      Location:427481
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    2. NM_001360390.1NP_001347319.1  meiotic recombination protein REC8 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC174678, BC052155
      Conserved Domains (1) summary
      pfam04824
      Location:331385
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    3. NM_020002.3NP_064386.2  meiotic recombination protein REC8 homolog isoform 1

      See identical proteins and their annotated locations for NP_064386.2

      Status: VALIDATED

      Source sequence(s)
      AC174678, AU080225, BC052155
      Consensus CDS
      CCDS27120.1
      UniProtKB/Swiss-Prot
      Q3UIN9, Q8C5S7, Q9JK52
      Related
      ENSMUSP00000002395.8, ENSMUST00000002395.8
      Conserved Domains (2) summary
      pfam04824
      Location:536590
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
      pfam04825
      Location:1112
      Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55855459..55862852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001781136.2 RNA Sequence