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    Snx2 sorting nexin 2 [ Mus musculus (house mouse) ]

    Gene ID: 67804, updated on 9-Dec-2024

    Summary

    Official Symbol
    Snx2provided by MGI
    Official Full Name
    sorting nexin 2provided by MGI
    Primary source
    MGI:MGI:1915054
    See related
    Ensembl:ENSMUSG00000034484 AllianceGenome:MGI:1915054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610030A03Rik
    Summary
    Predicted to enable phosphatidylinositol binding activity; protein dimerization activity; and signaling receptor binding activity. Predicted to be involved in early endosome to Golgi transport and lamellipodium morphogenesis. Located in membrane. Is expressed in embryo; neocortex; small intestine; and yolk sac. Orthologous to human SNX2 (sorting nexin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 55.9), bladder adult (RPKM 30.8) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Snx2 in Genome Data Viewer
    Location:
    18 D1; 18 28.99 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (53309362..53353938)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (53176292..53220866)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene synuclein, alpha interacting protein (synphilin) Neighboring gene STARR-seq mESC enhancer starr_44606 Neighboring gene STARR-seq mESC enhancer starr_44607 Neighboring gene predicted gene, 50457 Neighboring gene STARR-seq mESC enhancer starr_44608 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_44612 Neighboring gene STARR-positive B cell enhancer ABC_E5658 Neighboring gene STARR-positive B cell enhancer ABC_E7586 Neighboring gene STARR-positive B cell enhancer ABC_E4250 Neighboring gene Rac GTPase-activating protein 1 pseudogene Neighboring gene predicted gene, 54042 Neighboring gene sorting nexing 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables leptin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables leptin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in early endosome to Golgi transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of retromer, tubulation complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of retromer, tubulation complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357463.1NP_001344392.1  sorting nexin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127421, AC148020
      UniProtKB/TrEMBL
      Q3U5L3, Q91VZ1
      Conserved Domains (3) summary
      cd07282
      Location:142265
      PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2
      pfam03700
      Location:49112
      Sorting_nexin; Sorting nexin, N-terminal domain
      cl12013
      Location:283520
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_026386.2NP_080662.1  sorting nexin-2 isoform 1

      See identical proteins and their annotated locations for NP_080662.1

      Status: VALIDATED

      Source sequence(s)
      AC127421, AC148020, AK002692, AK145840
      Consensus CDS
      CCDS37821.1
      UniProtKB/Swiss-Prot
      Q3UKW3, Q9CQV0, Q9CWK8
      UniProtKB/TrEMBL
      Q3U5L3, Q91VZ1
      Related
      ENSMUSP00000039243.5, ENSMUST00000037850.7
      Conserved Domains (4) summary
      cd07282
      Location:142265
      PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2
      COG5391
      Location:51509
      COG5391; Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]
      pfam03700
      Location:49112
      Sorting_nexin; Sorting nexin, N-terminal domain
      cl12013
      Location:283516
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      53309362..53353938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161259.1XP_036017152.1  sorting nexin-2 isoform X3

      Conserved Domains (2) summary
      cd07282
      Location:20143
      PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2
      cl12013
      Location:161398
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_036161260.1XP_036017153.1  sorting nexin-2 isoform X4

      Conserved Domains (2) summary
      cd07282
      Location:20143
      PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2
      cl12013
      Location:161394
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. XM_030250577.2XP_030106437.1  sorting nexin-2 isoform X1

      UniProtKB/TrEMBL
      Q3U5L3, Q91VZ1
      Conserved Domains (3) summary
      cd07282
      Location:90213
      PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2
      pfam03700
      Location:2482
      Sorting_nexin; Sorting nexin, N-terminal domain
      cl12013
      Location:231468
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. XM_036161258.1XP_036017151.1  sorting nexin-2 isoform X2

      UniProtKB/TrEMBL
      Q3U5L3, Q91VZ1
      Conserved Domains (2) summary
      cd07282
      Location:90213
      PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2
      cl12013
      Location:231464
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature