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    Osbpl2 oxysterol binding protein-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 228983, updated on 27-Nov-2024

    Summary

    Official Symbol
    Osbpl2provided by MGI
    Official Full Name
    oxysterol binding protein-like 2provided by MGI
    Primary source
    MGI:MGI:2442832
    See related
    Ensembl:ENSMUSG00000039050 AllianceGenome:MGI:2442832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Orp2; ORP-2; C130070J12Rik
    Summary
    Predicted to enable cholesterol binding activity; lipid transfer activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in regulation of presynaptic cytosolic calcium ion concentration. Is active in glutamatergic synapse and presynaptic active zone cytoplasmic component. Is expressed in several structures, including central nervous system; genitourinary system; heart; immune system; and lung. Used to study autosomal dominant nonsyndromic deafness 67. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 67. Orthologous to human OSBPL2 (oxysterol binding protein like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 29.7), genital fat pad adult (RPKM 20.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Osbpl2 in Genome Data Viewer
    Location:
    2 H4; 2 102.64 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179758059..179804475)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180116318..180162682)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46782 Neighboring gene histamine receptor H3 Neighboring gene STARR-positive B cell enhancer ABC_E332 Neighboring gene predicted gene, 29886 Neighboring gene STARR-positive B cell enhancer mm9_chr2:179905789-179906089 Neighboring gene adhesion regulating molecule 1 26S proteasome ubiquitin receptor Neighboring gene laminin, alpha 5 Neighboring gene microRNA 7005

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • KIAA0772, MGC28451

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cholesterol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylinositol transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of presynaptic cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle priming IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    oxysterol-binding protein-related protein 2
    Names
    OSBP-related protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144500.4NP_653083.2  oxysterol-binding protein-related protein 2

      See identical proteins and their annotated locations for NP_653083.2

      Status: VALIDATED

      Source sequence(s)
      AL663027, AL672130
      Consensus CDS
      CCDS17170.1
      UniProtKB/Swiss-Prot
      Q3TCK8, Q8BX94, Q8R0H8
      UniProtKB/TrEMBL
      Q3TDA1
      Related
      ENSMUSP00000046538.9, ENSMUST00000040668.9
      Conserved Domains (1) summary
      pfam01237
      Location:75474
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      179758059..179804475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250794.2XP_030106654.1  oxysterol-binding protein-related protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TCK8, Q8BX94, Q8R0H8
      UniProtKB/TrEMBL
      Q3TDA1
      Conserved Domains (1) summary
      pfam01237
      Location:75474
      Oxysterol_BP; Oxysterol-binding protein
    2. XM_017317993.2XP_017173482.1  oxysterol-binding protein-related protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TCK8, Q8BX94, Q8R0H8
      UniProtKB/TrEMBL
      Q3TDA1
      Conserved Domains (1) summary
      pfam01237
      Location:75474
      Oxysterol_BP; Oxysterol-binding protein