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    Ftmt ferritin mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 67634, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ftmtprovided by MGI
    Official Full Name
    ferritin mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1914884
    See related
    Ensembl:ENSMUSG00000024510 AllianceGenome:MGI:1914884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MtF; FerH; Fth3; 4930447C24Rik
    Summary
    Enables ferroxidase activity. Predicted to be involved in several processes, including intracellular iron ion homeostasis; positive regulation of aconitate hydratase activity; and positive regulation of succinate dehydrogenase activity. Located in mitochondrion. Orthologous to human FTMT (ferritin mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Ftmt in Genome Data Viewer
    Location:
    18 D1; 18 28.19 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (52464608..52466068)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (52331536..52332996)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41723 Neighboring gene STARR-seq mESC enhancer starr_44597 Neighboring gene STARR-seq mESC enhancer starr_44598 Neighboring gene STARR-seq mESC enhancer starr_44599 Neighboring gene predicted gene, 22259 Neighboring gene STARR-seq mESC enhancer starr_44600 Neighboring gene STARR-seq mESC enhancer starr_44601 Neighboring gene STARR-positive B cell enhancer ABC_E7585 Neighboring gene STARR-seq mESC enhancer starr_44602 Neighboring gene serum response factor binding protein 1 Neighboring gene lysyl oxidase

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC144339, MGC144340

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ferroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ferroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ferroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ferroxidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    ferritin, mitochondrial
    Names
    ferritin H
    ferritin heavy chain 3
    NP_080562.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026286.3NP_080562.2  ferritin, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AK015400, AK133009
      Consensus CDS
      CCDS29246.1
      UniProtKB/Swiss-Prot
      Q14BZ8, Q3V0N6, Q9D5F4, Q9D5H4
      Related
      ENSMUSP00000025388.6, ENSMUST00000025388.7
      Conserved Domains (2) summary
      cd01056
      Location:69229
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:73211
      Ferritin; Ferritin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      52464608..52466068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)