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    qin qin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42236, updated on 9-Dec-2024

    Summary

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    Official Symbol
    qinprovided by FlyBase
    Official Full Name
    qinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263974
    Locus tag
    Dmel_CG43726
    See related
    AllianceGenome:FB:FBgn0263974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14303; CG14306; CG43726; Dmel\CG43726; kumo; Qin
    Old locus tag
    Dmel_CG14303; Dmel_CG14306
    Summary
    Predicted to enable zinc ion binding activity. Involved in piRNA-mediated retrotransposon silencing by mRNA destabilization and secondary piRNA processing. Located in P granule and nucleus. Is expressed in germarium and nurse cell. Orthologous to human RNF17 (ring finger protein 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See qin in Genome Data Viewer
    Location:
    91B5-91B8; 3-64 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18591027..18650137)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14416749..14475859)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hemotin Neighboring gene uncharacterized protein Neighboring gene frayed Neighboring gene uncharacterized protein Neighboring gene Testis-specific serine/threonine kinase Neighboring gene transfer RNA:Proline-TGG 1-5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cleavage stimulation factor 64 kD subunit Neighboring gene Cleavage and polyadenylation specificity factor 73 Neighboring gene Golgi SNARE, 28 kDa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tudor-domain containing proteins act to make the piRNA pathways more robust in Drosophila. Sato K, et al. Fly (Austin), 2015. PMID 26647059, Free PMC Article
    2. Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin. Zhang Z, et al. EMBO J, 2014 Mar 18. PMID 24652836, Free PMC Article
    3. Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains. Zhang Z, et al. Mol Cell, 2011 Nov 18. PMID 22099305, Free PMC Article
    4. Spindle-E cycling between nuage and cytoplasm is controlled by Qin and PIWI proteins. Andress A, et al. J Cell Biol, 2016 Apr 25. PMID 27091448, Free PMC Article
    5. The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing. Zhang Z, et al. Cell, 2014 Jun 5. PMID 24906152, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P granule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in secondary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transposable element silencing by piRNA-mediated mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    qin
    Names
    CG43726-PB
    kumo
    qin-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18591027..18650137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142478.3 → NP_650735.3  qin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650735.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MTA5, Q9VE55
      Conserved Domains (4) summary
      cd04508
      Location:1710 → 1761
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      smart00336
      Location:139 → 174
      BBOX; B-Box-type zinc finger
      pfam00567
      Location:536 → 648
      TUDOR; Tudor domain
      pfam14634
      Location:25 → 75
      zf-RING_5; zinc-RING finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MTA5 Q8MTA5
    Q9VE55 Q9VE55

    Gene LinkOut

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