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    Mylpf myosin light chain, phosphorylatable, fast skeletal muscle [ Mus musculus (house mouse) ]

    Gene ID: 17907, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mylpfprovided by MGI
    Official Full Name
    myosin light chain, phosphorylatable, fast skeletal muscleprovided by MGI
    Primary source
    MGI:MGI:97273
    See related
    Ensembl:ENSMUSG00000030672 AllianceGenome:MGI:97273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mlc2; MLC-2; Myl11; 2410014J02Rik
    Summary
    A structural constituent of muscle. Involved in skeletal muscle tissue development. Predicted to be part of myosin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including arterial system; embryo mesenchyme; eye; limb; and musculature. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C. Orthologous to human MYL11 (myosin light chain 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 230.4), limb E14.5 (RPKM 172.5) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Mylpf in Genome Data Viewer
    Location:
    7 F3; 7 69.39 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126808071..126813459)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127208848..127214288)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4977 Neighboring gene CD2 cytoplasmic tail binding protein 2 Neighboring gene TBC1 domain family, member 10b Neighboring gene STARR-positive B cell enhancer ABC_E158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134353944-134354145 Neighboring gene septin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134361531-134361732 Neighboring gene STARR-seq mESC enhancer starr_20173 Neighboring gene STARR-seq mESC enhancer starr_20176 Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553 Neighboring gene STARR-seq mESC enhancer starr_20179 Neighboring gene STARR-positive B cell enhancer ABC_E6605 Neighboring gene zinc finger protein 771

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of muscle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myosin regulatory light chain 11
    Names
    MLC2F
    fast skeletal myosin light chain 2
    myosin light chain 11
    myosin light chain 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347655.1NP_001334584.1  myosin regulatory light chain 11 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC122537
      Consensus CDS
      CCDS85420.1
      UniProtKB/TrEMBL
      A0A0U1RP93
      Related
      ENSMUSP00000145886.2, ENSMUST00000206772.2
      Conserved Domains (1) summary
      COG5126
      Location:1134
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    2. NM_016754.5NP_058034.1  myosin regulatory light chain 11 isoform 1

      See identical proteins and their annotated locations for NP_058034.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122537
      Consensus CDS
      CCDS40140.1
      UniProtKB/Swiss-Prot
      P97457
      UniProtKB/TrEMBL
      Q545G1
      Related
      ENSMUSP00000032910.7, ENSMUST00000032910.13
      Conserved Domains (1) summary
      COG5126
      Location:15154
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126808071..126813459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)