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    Mfge8 milk fat globule EGF and factor V/VIII domain containing [ Mus musculus (house mouse) ]

    Gene ID: 17304, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mfge8provided by MGI
    Official Full Name
    milk fat globule EGF and factor V/VIII domain containingprovided by MGI
    Primary source
    MGI:MGI:102768
    See related
    Ensembl:ENSMUSG00000030605 AllianceGenome:MGI:102768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P47; MP47; Mfgm; SED1; MFG-E8; lactadherin
    Summary
    Enables integrin binding activity. Involved in apoptotic cell clearance. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including central nervous system; extraembryonic component; hemolymphoid system; integumental system; and reproductive system. Human ortholog(s) of this gene implicated in temporal arteritis. Orthologous to human MFGE8 (milk fat globule EGF and factor V/VIII domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 1673.1), spleen adult (RPKM 373.7) and 7 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mfge8 in Genome Data Viewer
    Location:
    7 D2; 7 44.9 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (78783516..78798808, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79133768..79149060, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26633 Neighboring gene aggrecan Neighboring gene STARR-seq mESC enhancer starr_19258 Neighboring gene hyaluronan and proteoglycan link protein 3 Neighboring gene STARR-seq mESC enhancer starr_19263 Neighboring gene STARR-seq mESC enhancer starr_19264 Neighboring gene predicted gene, 39040 Neighboring gene STARR-seq mESC enhancer starr_19267 Neighboring gene STARR-positive B cell enhancer ABC_E47 Neighboring gene predicted gene, 31510

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic cell clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lactadherin
    Names
    EGF/factor VIII
    milk fat globule glycoprotein
    milk fat globule-EGF factor 8 protein
    sperm surface protein SP47

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045489.1NP_001038954.1  lactadherin isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC110520, AK087555, AK148371, CD776821
      Consensus CDS
      CCDS39989.1
      UniProtKB/TrEMBL
      Q3TDU5
      Related
      ENSMUSP00000103032.4, ENSMUST00000107409.5
      Conserved Domains (2) summary
      cd00057
      Location:273425
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00008
      Location:68106
      EGF; EGF-like domain
    2. NM_008594.2NP_032620.2  lactadherin isoform 1 precursor

      See identical proteins and their annotated locations for NP_032620.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AC110520, AK152088, CD776821
      Consensus CDS
      CCDS21379.1
      UniProtKB/Swiss-Prot
      P21956, P97800, Q3TBN5, Q3U8S9, Q9R1X9, Q9WTS3
      UniProtKB/TrEMBL
      Q3TDU5
      Related
      ENSMUSP00000032825.9, ENSMUST00000032825.14
      Conserved Domains (3) summary
      smart00231
      Location:307463
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:310462
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00008
      Location:68106
      EGF; EGF-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      78783516..78798808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)