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    Acin1 apoptotic chromatin condensation inducer 1 [ Mus musculus (house mouse) ]

    Gene ID: 56215, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acin1provided by MGI
    Official Full Name
    apoptotic chromatin condensation inducer 1provided by MGI
    Primary source
    MGI:MGI:1891824
    See related
    Ensembl:ENSMUSG00000022185 AllianceGenome:MGI:1891824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acn; Acinus; acinusL; acinusS; mKIAA0670; 2610036I19Rik; 2610510L13Rik
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be involved in several processes, including apoptotic chromosome condensation; negative regulation of mRNA splicing, via spliceosome; and positive regulation of monocyte differentiation. Predicted to act upstream of or within apoptotic process. Located in nucleolus. Is expressed in several structures, including central nervous system; connective tissue; early conceptus; olfactory epithelium; and retina. Orthologous to human ACIN1 (apoptotic chromatin condensation inducer 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 53.8), CNS E14 (RPKM 33.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Acin1 in Genome Data Viewer
    Location:
    14 C2; 14 27.87 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54879618..54924422, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54642161..54686965, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type, 11 Neighboring gene cadherin-like 24 Neighboring gene microRNA 6948 Neighboring gene RIKEN cDNA 4930579G18 gene Neighboring gene STARR-positive B cell enhancer ABC_E1473 Neighboring gene RIKEN cDNA 1700123O20 gene Neighboring gene STARR-positive B cell enhancer ABC_E96 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene ciliated left-right organizer metallopeptidase Neighboring gene predicted gene, 53859

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic chromosome condensation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of monocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of ASAP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ASAP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ASAP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exon-exon junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    apoptotic chromatin condensation inducer in the nucleus

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085472.2NP_001078941.2  apoptotic chromatin condensation inducer in the nucleus isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      BC052755, BC094217, BY287113
      Consensus CDS
      CCDS49492.1
      UniProtKB/TrEMBL
      B8JJ92
      Related
      ENSMUSP00000122003.4, ENSMUST00000148754.10
      Conserved Domains (2) summary
      cd12432
      Location:253339
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:407482
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    2. NM_001085473.2NP_001078942.2  apoptotic chromatin condensation inducer in the nucleus isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the mid coding region, compared to variant 1. The resulting isoform (4) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF168782, AK011698, AK050467, AK122342, BC094217
      UniProtKB/TrEMBL
      F6RJ39
      Related
      ENSMUSP00000119080.2, ENSMUST00000147714.8
      Conserved Domains (3) summary
      smart00513
      Location:72106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:9981084
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:11521227
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    3. NM_001242605.1NP_001229534.1  apoptotic chromatin condensation inducer in the nucleus isoform 5

      See identical proteins and their annotated locations for NP_001229534.1

      Status: VALIDATED

      Description
      This variant (5) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which is associated with a strong Kozak sequence.
      Source sequence(s)
      AF124729, BC094217, BY295579
      Consensus CDS
      CCDS56957.1
      UniProtKB/TrEMBL
      B8JJ92
      Related
      ENSMUSP00000114546.2, ENSMUST00000126166.8
      Conserved Domains (2) summary
      cd12432
      Location:237323
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:432466
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    4. NM_001242606.1NP_001229535.1  apoptotic chromatin condensation inducer in the nucleus isoform 6

      See identical proteins and their annotated locations for NP_001229535.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks a 5' exon and uses an alternate splice site in the coding region compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which is associated with a strong Kozak sequence.
      Source sequence(s)
      BC094217, BY295579
      Consensus CDS
      CCDS56956.1
      UniProtKB/TrEMBL
      Q52KR6
      Related
      ENSMUSP00000116664.2, ENSMUST00000141453.8
      Conserved Domains (2) summary
      cd12432
      Location:224310
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:419453
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    5. NM_001374770.1NP_001361699.1  apoptotic chromatin condensation inducer in the nucleus isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT009512
      Consensus CDS
      CCDS88664.1
      UniProtKB/TrEMBL
      F6RJ39
      Related
      ENSMUSP00000107109.3, ENSMUST00000111484.9
      Conserved Domains (5) summary
      smart00513
      Location:72106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:9701056
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      TIGR01348
      Location:373507
      PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam02463
      Location:86376
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam16294
      Location:11651199
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    6. NM_019567.3NP_062513.3  apoptotic chromatin condensation inducer in the nucleus isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AF124725, BC094217, BY295579, BY711288
      Consensus CDS
      CCDS27098.2
      UniProtKB/TrEMBL
      B8JJ91
      Related
      ENSMUSP00000118069.2, ENSMUST00000150371.8
      Conserved Domains (2) summary
      cd12432
      Location:306392
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:460535
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    7. NM_023190.3NP_075679.2  apoptotic chromatin condensation inducer in the nucleus isoform 2

      See identical proteins and their annotated locations for NP_075679.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF168782, AK011698, AK030449, BC094217
      Consensus CDS
      CCDS27097.1
      UniProtKB/Swiss-Prot
      B8JJ87, Q9CSN7, Q9CSR9, Q9CSX7, Q9JIX8, Q9R046, Q9R047
      UniProtKB/TrEMBL
      F6RJ39
      Related
      ENSMUSP00000022793.9, ENSMUST00000022793.15
      Conserved Domains (3) summary
      smart00513
      Location:72106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:10101096
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:11641239
      RSB_motif; RNSP1-SAP18 binding (RSB) motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54879618..54924422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247893.2XP_030103753.1  apoptotic chromatin condensation inducer in the nucleus isoform X3

      UniProtKB/TrEMBL
      F6RJ39
      Conserved Domains (5) summary
      smart00513
      Location:72106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:9691055
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      TIGR01348
      Location:373507
      PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam02463
      Location:86376
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam16294
      Location:11641198
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    2. XM_030247894.2XP_030103754.1  apoptotic chromatin condensation inducer in the nucleus isoform X4

      UniProtKB/TrEMBL
      F6RJ39
      Conserved Domains (5) summary
      smart00513
      Location:72106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:9581044
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      TIGR01348
      Location:373507
      PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam02463
      Location:86376
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam16294
      Location:11531187
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    3. XM_006519297.3XP_006519360.1  apoptotic chromatin condensation inducer in the nucleus isoform X2

      UniProtKB/TrEMBL
      F6RJ39
      Conserved Domains (5) summary
      smart00513
      Location:72106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PTZ00121
      Location:210416
      PTZ00121; MAEBL; Provisional
      cd12432
      Location:9971083
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      TIGR01348
      Location:413547
      PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam16294
      Location:11921226
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    4. XM_006519296.3XP_006519359.1  apoptotic chromatin condensation inducer in the nucleus isoform X1

      UniProtKB/TrEMBL
      F6RJ39
      Conserved Domains (5) summary
      smart00513
      Location:72106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PTZ00121
      Location:210416
      PTZ00121; MAEBL; Provisional
      cd12432
      Location:10091095
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      TIGR01348
      Location:413547
      PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam16294
      Location:12041238
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    5. XM_006519308.4XP_006519371.1  apoptotic chromatin condensation inducer in the nucleus isoform X9

      See identical proteins and their annotated locations for XP_006519371.1

      UniProtKB/TrEMBL
      Q52KR6
      Conserved Domains (2) summary
      cd12432
      Location:224310
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:419453
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    6. XM_006519304.4XP_006519367.1  apoptotic chromatin condensation inducer in the nucleus isoform X8

      See identical proteins and their annotated locations for XP_006519367.1

      UniProtKB/TrEMBL
      B8JJ92
      Conserved Domains (2) summary
      cd12432
      Location:237323
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:432466
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    7. XM_006519301.2XP_006519364.1  apoptotic chromatin condensation inducer in the nucleus isoform X5

      Conserved Domains (2) summary
      cd12432
      Location:319405
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:514548
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    8. XM_030247896.1XP_030103756.1  apoptotic chromatin condensation inducer in the nucleus isoform X7

      Conserved Domains (2) summary
      cd12432
      Location:293379
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:488522
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    9. XM_030247895.1XP_030103755.1  apoptotic chromatin condensation inducer in the nucleus isoform X6

      Conserved Domains (2) summary
      cd12432
      Location:306392
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:501535
      RSB_motif; RNSP1-SAP18 binding (RSB) motif

    RNA

    1. XR_004938418.1 RNA Sequence

    2. XR_003950876.2 RNA Sequence

    3. XR_003950874.2 RNA Sequence

    4. XR_004938423.1 RNA Sequence

    5. XR_003950872.2 RNA Sequence

    6. XR_003950870.2 RNA Sequence

    7. XR_004938420.1 RNA Sequence

    8. XR_004938419.1 RNA Sequence

    9. XR_003950871.2 RNA Sequence

    10. XR_004938422.1 RNA Sequence

    11. XR_004938421.1 RNA Sequence