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    Esr1 estrogen receptor 1 (alpha) [ Mus musculus (house mouse) ]

    Gene ID: 13982, updated on 3-Dec-2024

    Summary

    Official Symbol
    Esr1provided by MGI
    Official Full Name
    estrogen receptor 1 (alpha)provided by MGI
    Primary source
    MGI:MGI:1352467
    See related
    Ensembl:ENSMUSG00000019768 AllianceGenome:MGI:1352467
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ER; ERa; ESR; Estr; Estra; Nr3a1; ERalpha; ER-alpha
    Summary
    This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Biased expression in ovary adult (RPKM 13.9), subcutaneous fat pad adult (RPKM 12.1) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Esr1 in Genome Data Viewer
    Location:
    10 A1; 10 2.03 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4561989..4955633)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (4611989..5005633)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25624 Neighboring gene coiled-coil domain containing 170 Neighboring gene predicted gene, 22739 Neighboring gene STARR-seq mESC enhancer starr_25622 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5733988-5734171 Neighboring gene STARR-seq mESC enhancer starr_25621 Neighboring gene glutathione S-transferase, pi 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25620 Neighboring gene STARR-seq mESC enhancer starr_25619 Neighboring gene STARR-seq mESC enhancer starr_25618 Neighboring gene STARR-seq mESC enhancer starr_25616 Neighboring gene STARR-seq mESC enhancer starr_25614 Neighboring gene STARR-seq mESC enhancer starr_25613 Neighboring gene STARR-seq mESC enhancer starr_25612 Neighboring gene spectrin repeat containing, nuclear envelope 1 Neighboring gene STARR-positive B cell enhancer ABC_E2314 Neighboring gene STARR-seq mESC enhancer starr_25609 Neighboring gene STARR-seq mESC enhancer starr_25607 Neighboring gene predicted gene, 51757 Neighboring gene predicted gene, 23573

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled estrogen receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TFIIB-class transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TFIIB-class transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables estrogen response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables estrogen response element binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables estrogen response element binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear estrogen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear estrogen receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear estrogen receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear steroid receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol 3-kinase regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coactivator binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables type 1 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Sertoli cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within androgen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within antral ovarian follicle growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to estradiol stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to estrogen stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to estrogen stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in estrogen receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland branching involved in pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of miRNA transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitotic nuclear division NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear receptor-mediated steroid hormone signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear receptor-mediated steroid hormone signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric-oxide synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within prostate epithelial cord elongation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to estradiol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stem cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in steroid hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within uterus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within vagina development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in euchromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    estrogen receptor
    Names
    C-terminally-truncated estrogen receptor alpha product-4
    C-terminally-truncated estrogen receptor alpha product-5
    C-terminally-truncated estrogen receptor alpha product-6
    C-terminally-truncated estrogen receptor alpha product-7
    estradiol receptor
    nuclear receptor subfamily 3 group A member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302531.2NP_001289460.1  estrogen receptor isoform 1

      See identical proteins and their annotated locations for NP_001289460.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 6 all encode the same isoform (1).
      Source sequence(s)
      AC153573, AC156393
      Consensus CDS
      CCDS56678.1
      UniProtKB/Swiss-Prot
      P19785, Q9JJT5, Q9QY51, Q9QY52
      UniProtKB/TrEMBL
      B3VQI7, E7FJU2
      Related
      ENSMUSP00000101214.2, ENSMUST00000105589.2
      Conserved Domains (4) summary
      cd06949
      Location:314551
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:184265
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42185
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556599
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    2. NM_001302532.2NP_001289461.1  estrogen receptor isoform 1

      See identical proteins and their annotated locations for NP_001289461.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 6 all encode the same isoform (1).
      Source sequence(s)
      AC153573, AC156393, AC158617
      Consensus CDS
      CCDS56678.1
      UniProtKB/Swiss-Prot
      P19785, Q9JJT5, Q9QY51, Q9QY52
      UniProtKB/TrEMBL
      B3VQI7, E7FJU2
      Related
      ENSMUSP00000101215.2, ENSMUST00000105590.8
      Conserved Domains (4) summary
      cd06949
      Location:314551
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:184265
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42185
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556599
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    3. NM_001302533.2NP_001289462.1  estrogen receptor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon in the 3' coding region and uses an upstream alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC153573, AC156393
      UniProtKB/TrEMBL
      D3Z6V3
      Related
      ENSMUSP00000101213.2, ENSMUST00000105588.8
      Conserved Domains (3) summary
      cd07171
      Location:184265
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42185
      Oest_recep; Oestrogen receptor
      cl11397
      Location:314416
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    4. NM_001428459.1NP_001415388.1  estrogen receptor isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC153573, AC156393, AC158617
      UniProtKB/Swiss-Prot
      P19785, Q9JJT5, Q9QY51, Q9QY52
      UniProtKB/TrEMBL
      B3VQI7, E7FJU2
    5. NM_007956.6NP_031982.1  estrogen receptor isoform 1

      See identical proteins and their annotated locations for NP_031982.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, 3, and 6 all encode the same isoform (1).
      Source sequence(s)
      AC153573, AC156393, AC158617
      Consensus CDS
      CCDS56678.1
      UniProtKB/Swiss-Prot
      P19785, Q9JJT5, Q9QY51, Q9QY52
      UniProtKB/TrEMBL
      B3VQI7, E7FJU2
      Related
      ENSMUSP00000070070.8, ENSMUST00000067086.14
      Conserved Domains (4) summary
      cd06949
      Location:314551
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:184265
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42185
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556599
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    RNA

    1. NR_126357.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate exon in the 5' region, contains an alternate internal exon and uses an upstream alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC153573, AC158617, AC158639
      Related
      ENSMUST00000149195.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      4561989..4955633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243066.4XP_011241368.1  estrogen receptor isoform X1

      See identical proteins and their annotated locations for XP_011241368.1

      UniProtKB/Swiss-Prot
      P19785, Q9JJT5, Q9QY51, Q9QY52
      UniProtKB/TrEMBL
      B3VQI7, E7FJU2
      Conserved Domains (4) summary
      cd06949
      Location:314551
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:184265
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42185
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556599
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    2. XM_011243068.4XP_011241370.1  estrogen receptor isoform X1

      See identical proteins and their annotated locations for XP_011241370.1

      UniProtKB/Swiss-Prot
      P19785, Q9JJT5, Q9QY51, Q9QY52
      UniProtKB/TrEMBL
      B3VQI7, E7FJU2
      Conserved Domains (4) summary
      cd06949
      Location:314551
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:184265
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42185
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556599
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    3. XM_006512435.3XP_006512498.1  estrogen receptor isoform X1

      See identical proteins and their annotated locations for XP_006512498.1

      UniProtKB/Swiss-Prot
      P19785, Q9JJT5, Q9QY51, Q9QY52
      UniProtKB/TrEMBL
      B3VQI7, E7FJU2
      Conserved Domains (4) summary
      cd06949
      Location:314551
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:184265
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42185
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556599
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    4. XM_006512434.5XP_006512497.1  estrogen receptor isoform X1

      See identical proteins and their annotated locations for XP_006512497.1

      UniProtKB/Swiss-Prot
      P19785, Q9JJT5, Q9QY51, Q9QY52
      UniProtKB/TrEMBL
      B3VQI7, E7FJU2
      Conserved Domains (4) summary
      cd06949
      Location:314551
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:184265
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42185
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556599
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    5. XM_036155590.1XP_036011483.1  estrogen receptor isoform X2

      UniProtKB/TrEMBL
      A0A1W7GYW9, A0A1W7GYY4
      Conserved Domains (3) summary
      cd07171
      Location:184265
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42185
      Oest_recep; Oestrogen receptor
      cl11397
      Location:314370
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    6. XM_006512433.5XP_006512496.1  estrogen receptor isoform X1

      See identical proteins and their annotated locations for XP_006512496.1

      UniProtKB/Swiss-Prot
      P19785, Q9JJT5, Q9QY51, Q9QY52
      UniProtKB/TrEMBL
      B3VQI7, E7FJU2
      Conserved Domains (4) summary
      cd06949
      Location:314551
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:184265
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42185
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556599
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal